Opiorphin in burning mouth syndrome patients: a case-control study

Opiorphin in burning mouth syndrome patients: a case-control study Clin Oral Invest (2017) 21:2363–2370 DOI 10.1007/s00784-016-2031-9 ORIGINAL ARTICLE Opiorphin in burning mouth syndrome patients: a case-control study 1 2 3 Ivan Salarić & Maja Sabalić & Ivan Alajbeg Received: 9 May 2016 /Accepted: 7 December 2016 /Published online: 24 December 2016 Springer-Verlag Berlin Heidelberg 2017 Abstract emotional and behavioral imbalances possibly associated with Objectives Opiorphin is a pentapeptide isolated from human BMS. To our knowledge, this is the first original article mea- saliva that suppresses pain from chemically induced inflam- suring opiorphin in a pain disorder. mation and acute physical pain. Burning mouth syndrome Clinical relevance Opiorphin may be a measurable biomarker (BMS) is a chronic condition of a burning sensation in the for chronic pain, which could help in objectifying otherwise mouth, where no underlying dental or medical cause can be exclusively a subjective experience. Increased opiorphin identified. We aimed to measure the level of opiorphin in could serve as a universal objective indicator of painful con- whole unstimulated (UWS) and stimulated (SWS) saliva of ditions. Since opiorphin may also reflect emotional and socio- patients with BMS. relational imbalances occurring with BMS, it could as well Materials and methods Originally developed and validated represent a biomarker for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Oral Investigations Springer Journals

Opiorphin in burning mouth syndrome patients: a case-control study

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Dentistry; Dentistry
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