Clin Oral Invest (2017) 21:2363–2370 DOI 10.1007/s00784-016-2031-9 ORIGINAL ARTICLE Opiorphin in burning mouth syndrome patients: a case-control study 1 2 3 Ivan Salarić & Maja Sabalić & Ivan Alajbeg Received: 9 May 2016 /Accepted: 7 December 2016 /Published online: 24 December 2016 Springer-Verlag Berlin Heidelberg 2017 Abstract emotional and behavioral imbalances possibly associated with Objectives Opiorphin is a pentapeptide isolated from human BMS. To our knowledge, this is the first original article mea- saliva that suppresses pain from chemically induced inflam- suring opiorphin in a pain disorder. mation and acute physical pain. Burning mouth syndrome Clinical relevance Opiorphin may be a measurable biomarker (BMS) is a chronic condition of a burning sensation in the for chronic pain, which could help in objectifying otherwise mouth, where no underlying dental or medical cause can be exclusively a subjective experience. Increased opiorphin identified. We aimed to measure the level of opiorphin in could serve as a universal objective indicator of painful con- whole unstimulated (UWS) and stimulated (SWS) saliva of ditions. Since opiorphin may also reflect emotional and socio- patients with BMS. relational imbalances occurring with BMS, it could as well Materials and methods Originally developed and validated represent a biomarker for
Clinical Oral Investigations – Springer Journals
Published: Dec 24, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera