CHO CHO O 80 °C Stirring O NH NH 2 O 2 CH CN SO NH 4 2 2 NH SO 2 2 20 mol% p-TSA O O O O 29 examples 12 examples SO NH NH 2 2 SO 2 2 Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2870-2) contains supplementary material, which is available to authorized users. & Appaswami Lalitha email@example.com Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India 123 4166 C. S. Maheswari et al. Keywords p-Toluenesulfonic acid Symmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide Unsymmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide Multicomponent reaction One-pot synthesis Introduction Acridine and its derivatives are important compounds, and acridine-1,8-diones containing a 1,4-dihydropyridine parent nucleus have attracted considerable attention due to their potential pharmacological activities. Acridine and its hydro derivatives are active against malaria , cancer , and leishmaniasis . In recent years, compounds with sulfonamide moiety have been considered an important group of organic compounds possessing a clinically active pharmacophore [4–9], exhibiting a wide variety of pharmacological properties, such as antibacterial , hypoglycemic , diuretic [12, 13], anti-carbonic anhydrase [12, 14], antithyroid , and anticancer activities [16, 17]. Due to their widespread biological applications, the present
Research on Chemical Intermediates – Springer Journals
Published: Jan 30, 2017
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