One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA

One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by... CHO CHO O 80 °C Stirring O NH NH 2 O 2 CH CN SO NH 4 2 2 NH SO 2 2 20 mol% p-TSA O O O O 29 examples 12 examples SO NH NH 2 2 SO 2 2 Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2870-2) contains supplementary material, which is available to authorized users. & Appaswami Lalitha lalitha2531@yahoo.co.in Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India 123 4166 C. S. Maheswari et al. Keywords p-Toluenesulfonic acid  Symmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide  Unsymmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide  Multicomponent reaction  One-pot synthesis Introduction Acridine and its derivatives are important compounds, and acridine-1,8-diones containing a 1,4-dihydropyridine parent nucleus have attracted considerable attention due to their potential pharmacological activities. Acridine and its hydro derivatives are active against malaria [1], cancer [2], and leishmaniasis [3]. In recent years, compounds with sulfonamide moiety have been considered an important group of organic compounds possessing a clinically active pharmacophore [4–9], exhibiting a wide variety of pharmacological properties, such as antibacterial [10], hypoglycemic [11], diuretic [12, 13], anti-carbonic anhydrase [12, 14], antithyroid [15], and anticancer activities [16, 17]. Due to their widespread biological applications, the present http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2870-2
Publisher site
See Article on Publisher Site

Abstract

CHO CHO O 80 °C Stirring O NH NH 2 O 2 CH CN SO NH 4 2 2 NH SO 2 2 20 mol% p-TSA O O O O 29 examples 12 examples SO NH NH 2 2 SO 2 2 Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2870-2) contains supplementary material, which is available to authorized users. & Appaswami Lalitha lalitha2531@yahoo.co.in Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636011, India 123 4166 C. S. Maheswari et al. Keywords p-Toluenesulfonic acid  Symmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide  Unsymmetrical 1,8-dioxo-octahydroacridine benzenesulfonamide  Multicomponent reaction  One-pot synthesis Introduction Acridine and its derivatives are important compounds, and acridine-1,8-diones containing a 1,4-dihydropyridine parent nucleus have attracted considerable attention due to their potential pharmacological activities. Acridine and its hydro derivatives are active against malaria [1], cancer [2], and leishmaniasis [3]. In recent years, compounds with sulfonamide moiety have been considered an important group of organic compounds possessing a clinically active pharmacophore [4–9], exhibiting a wide variety of pharmacological properties, such as antibacterial [10], hypoglycemic [11], diuretic [12, 13], anti-carbonic anhydrase [12, 14], antithyroid [15], and anticancer activities [16, 17]. Due to their widespread biological applications, the present

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 30, 2017

References

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