One-Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy

One-Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After... Introduction Hypocalcemia is a well-known complication after total thyroidectomy. Studies have indicated that the presence of low postoperative parathyroid hormone (PTH) levels can predict hypocalcemia. However, definitive study designs are lacking. The aim of this study was to determine whether postoperative PTH alone can accurately predict postoperative biochemical hypocalcemia. Methods Under IRB approval, a prospective study of 218 consecutive patients who underwent total or completion thyroidectomy by two surgeons between June 2014 and June 2016 was performed. Biochemical hypocalcemia was defined as ionized calcium \1.13 mmol/L or serum calcium \8.4 mg/dL at any time postoperatively. Three PTH thresholds, \10, \20 pg/mL, and [50% drop in PTH 1 h postoperatively from baseline were examined. Results Postoperative PTH \ 10 pg/mL had a sensitivity of 36.5% (95% CI 27.4–46.3%) and a specificity of 89.2% (95% CI 81.9–94.3%). Postoperative PTH \ 20 pg/mL had a sensitivity of 66.4% (95% CI 56.6–75.2%) and a specificity of 67.6% (95% CI 58.0–76.2%). Postoperative PTH decrease[50% had a sensitivity of 63.4% (95% CI 53.2–72.7%) and a specificity of 72.5% (95% CI 62.5–81.0%). Across all PTH thresholds, the false-negative rate was 33.6–63.5% indicating that up to 64% of patients with a normal PTH level could have been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Surgery Springer Journals

One-Hour Postoperative Parathyroid Hormone Levels Do Not Reliably Predict Hypocalcemia After Thyroidectomy

Loading next page...
 
/lp/springer_journal/one-hour-postoperative-parathyroid-hormone-levels-do-not-reliably-4YVUrwpY65
Publisher
Springer Journals
Copyright
Copyright © 2017 by Société Internationale de Chirurgie
Subject
Medicine & Public Health; Surgery; Abdominal Surgery; Cardiac Surgery; General Surgery; Thoracic Surgery; Vascular Surgery
ISSN
0364-2313
eISSN
1432-2323
D.O.I.
10.1007/s00268-017-4444-2
Publisher site
See Article on Publisher Site

Abstract

Introduction Hypocalcemia is a well-known complication after total thyroidectomy. Studies have indicated that the presence of low postoperative parathyroid hormone (PTH) levels can predict hypocalcemia. However, definitive study designs are lacking. The aim of this study was to determine whether postoperative PTH alone can accurately predict postoperative biochemical hypocalcemia. Methods Under IRB approval, a prospective study of 218 consecutive patients who underwent total or completion thyroidectomy by two surgeons between June 2014 and June 2016 was performed. Biochemical hypocalcemia was defined as ionized calcium \1.13 mmol/L or serum calcium \8.4 mg/dL at any time postoperatively. Three PTH thresholds, \10, \20 pg/mL, and [50% drop in PTH 1 h postoperatively from baseline were examined. Results Postoperative PTH \ 10 pg/mL had a sensitivity of 36.5% (95% CI 27.4–46.3%) and a specificity of 89.2% (95% CI 81.9–94.3%). Postoperative PTH \ 20 pg/mL had a sensitivity of 66.4% (95% CI 56.6–75.2%) and a specificity of 67.6% (95% CI 58.0–76.2%). Postoperative PTH decrease[50% had a sensitivity of 63.4% (95% CI 53.2–72.7%) and a specificity of 72.5% (95% CI 62.5–81.0%). Across all PTH thresholds, the false-negative rate was 33.6–63.5% indicating that up to 64% of patients with a normal PTH level could have been

Journal

World Journal of SurgerySpringer Journals

Published: Dec 31, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off