One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans

One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2... Aims/hypothesis Elevated 2-h plasma glucose concentration (r = −0.384) was more closely associated with AIR, whereas, (2 h-PG) during a 75 g OGTT predict the development of type compared with 1 h-PG (r = −0.340), 2 h-PG (r = −0.408) was 2 diabetes mellitus. However, 1-h plasma glucose concentra- more closely associated with M. Measures of 1 h-PG and tion (1 h-PG) is associated with insulin secretion and may be a 2 h-PG had similar abilities to predict type 2 diabetes, which better predictor of type 2 diabetes. We aimed to investigate the did not change when both were included in the model. A association between 1 h-PG and 2 h-PG using gold standard 1 h-PG cut-off of 9.3 mmol/l provided similar levels of sensi- methods for measuring insulin secretion and action. We also tivity and specificity as a 2 h-PG cut-off of 7.8 mmol/l; the compared 1 h-PG and 2 h-PG as predictors of type 2 diabetes latter is used to define impaired glucose tolerance, a mellitus. recognised predictor of type 2 diabetes mellitus. Methods This analysis included adult volunteers without dia- Conclusions/interpretation The 1 h-PG was associated with betes, predominantly Native Americans of Southwestern her- important physiological http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans

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Publisher
Springer Journals
Copyright
Copyright © 2017 by US Government (outside the USA)
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
D.O.I.
10.1007/s00125-017-4332-1
Publisher site
See Article on Publisher Site

Abstract

Aims/hypothesis Elevated 2-h plasma glucose concentration (r = −0.384) was more closely associated with AIR, whereas, (2 h-PG) during a 75 g OGTT predict the development of type compared with 1 h-PG (r = −0.340), 2 h-PG (r = −0.408) was 2 diabetes mellitus. However, 1-h plasma glucose concentra- more closely associated with M. Measures of 1 h-PG and tion (1 h-PG) is associated with insulin secretion and may be a 2 h-PG had similar abilities to predict type 2 diabetes, which better predictor of type 2 diabetes. We aimed to investigate the did not change when both were included in the model. A association between 1 h-PG and 2 h-PG using gold standard 1 h-PG cut-off of 9.3 mmol/l provided similar levels of sensi- methods for measuring insulin secretion and action. We also tivity and specificity as a 2 h-PG cut-off of 7.8 mmol/l; the compared 1 h-PG and 2 h-PG as predictors of type 2 diabetes latter is used to define impaired glucose tolerance, a mellitus. recognised predictor of type 2 diabetes mellitus. Methods This analysis included adult volunteers without dia- Conclusions/interpretation The 1 h-PG was associated with betes, predominantly Native Americans of Southwestern her- important physiological

Journal

DiabetologiaSpringer Journals

Published: Jun 29, 2017

References

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