Oncogene-induced senescence and tumour control in complex biological systems

Oncogene-induced senescence and tumour control in complex biological systems Cell Death & Differentiation (2018) 25:1005–1006 https://doi.org/10.1038/s41418-018-0102-y EDITORIAL Oncogene-induced senescence and tumour control in complex biological systems 1,2,3 4,5,6 Lorenzo Galluzzi Ilio Vitale Received: 6 March 2018 / Accepted: 9 March 2018 / Published online: 17 April 2018 © ADMC Associazione Differenziamento e Morte Cellulare 2018 Mammalian cells experiencing potentially oncogenic con- autophagy, an evolutionarily old mechanism of adaptation ditions can undergo regulated cell death (RCD) [1] as well that is particularly important for the metabolic reprogram- as an irreversible proliferative arrest known as cellular ming and survival of senescent cells [6], in a model of G12V senescence [2]. Senescent cells are unable to proliferate HRAS -driven OIS. In the experimental setting G12V owing to the permanent upregulation of cell cycle inhibitors employed by Sulli and colleagues [5], however, HRAS [2], and are preferential targets for elimination by the overexpression results in approximately 60% of cells immune system [3]. Thus, the net effect of senescence at the staining positively for senescence-associated β galactosi- cell-intrinsic level is robust oncosuppression. However, dase (as they report in Extended Data Fig. 9), implying that senescent cells also release multiple cytokines that may approximately 40% cells retained proliferative potential. support the proliferation of non-senescent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Death & Differentiation Springer Journals

Oncogene-induced senescence and tumour control in complex biological systems

Loading next page...
 
/lp/springer_journal/oncogene-induced-senescence-and-tumour-control-in-complex-biological-neCj9NX0T0
Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by ADMC Associazione Differenziamento e Morte Cellulare
Subject
Life Sciences; Life Sciences, general; Biochemistry, general; Cell Biology; Stem Cells; Apoptosis; Cell Cycle Analysis
ISSN
1350-9047
eISSN
1476-5403
D.O.I.
10.1038/s41418-018-0102-y
Publisher site
See Article on Publisher Site

Abstract

Cell Death & Differentiation (2018) 25:1005–1006 https://doi.org/10.1038/s41418-018-0102-y EDITORIAL Oncogene-induced senescence and tumour control in complex biological systems 1,2,3 4,5,6 Lorenzo Galluzzi Ilio Vitale Received: 6 March 2018 / Accepted: 9 March 2018 / Published online: 17 April 2018 © ADMC Associazione Differenziamento e Morte Cellulare 2018 Mammalian cells experiencing potentially oncogenic con- autophagy, an evolutionarily old mechanism of adaptation ditions can undergo regulated cell death (RCD) [1] as well that is particularly important for the metabolic reprogram- as an irreversible proliferative arrest known as cellular ming and survival of senescent cells [6], in a model of G12V senescence [2]. Senescent cells are unable to proliferate HRAS -driven OIS. In the experimental setting G12V owing to the permanent upregulation of cell cycle inhibitors employed by Sulli and colleagues [5], however, HRAS [2], and are preferential targets for elimination by the overexpression results in approximately 60% of cells immune system [3]. Thus, the net effect of senescence at the staining positively for senescence-associated β galactosi- cell-intrinsic level is robust oncosuppression. However, dase (as they report in Extended Data Fig. 9), implying that senescent cells also release multiple cytokines that may approximately 40% cells retained proliferative potential. support the proliferation of non-senescent

Journal

Cell Death & DifferentiationSpringer Journals

Published: Apr 17, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off