On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior

On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans... Serotonin reduces the behavior tolerance of Caenorhabditis elegans of the N2 wild-type strain (swimming induced by the mechanical stimulus) to a temperature of 36°C. The sensitivity to the serotonin influence on the behavior thermotolerance remains intact in strains with null mutations of mod-1(ok103) and ser-1(ok345) serotonin receptor genes, and is almost completely lost in the ser-4(ok512) strain with null mutation in the gene of the SER-4 serotonin receptor, which is a homologue of 5-HT1 mammalian serotonin receptor. In addition, nematodes of the ser-4(ok512) strain have high behavior thermotolerance in the absence of the exogenous serotonin compared to the N2 strain. These data indicate the involvement of the ser-4 gene in the serotonin regulation of the tolerance of C. elegance nervous system functions to hyperthermia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior

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SP MAIK Nauka/Interperiodica
Copyright © 2013 by Pleiades Publishing, Ltd.
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
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