On-line packed magnetic in-tube solid phase microextraction of acidic drugs such as naproxen and indomethacin by using Fe3O4@SiO2@layered double hydroxide nanoparticles with high anion exchange capacity

On-line packed magnetic in-tube solid phase microextraction of acidic drugs such as naproxen and... The authors describe a 3-component nanoparticle system composed of a silica-coated magnetite (Fe3O4) core and a layered double (Cu-Cr) hydroxide nanoplatelet shell. The sorbent has a high anion exchange capacity for extraction anionic species. A simple online system, referred to as "on-line packed magnetic-in-tube solid phase microextraction" was designed. The nanoparticles were placed in a stainless steel cartridge via dry packing. The cartridge was then applied to the preconcentration acidic drugs including naproxen and indomethacin from urine and plasma. Extraction and desorption times, pH values of the sample solution and flow rates of sample solution and eluent were optimized. Analytes were then quantified by HPLC with UV detection. Under optimal conditions, the limits of detection range from 70 to 800 ng L−1, with linear responses from 0.1–500 μg L−1 (water samples), 0.6–500 μg L−1 (spiked urine), and 0.9–500 μg L−1 (spiked plasma). The inter- and intra-assay precisions (RSDs, for n = 5) are in the range of 2.2–5.4%, 2.8–4.9%, and 2.0–5.2% at concentration levels of 5, 25 and 50 μg L−1, respectively. The method was applied to the analysis of the drugs in spiked human urine and plasma, and good results were achieved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microchimica Acta Springer Journals

On-line packed magnetic in-tube solid phase microextraction of acidic drugs such as naproxen and indomethacin by using Fe3O4@SiO2@layered double hydroxide nanoparticles with high anion exchange capacity

Loading next page...
 
/lp/springer_journal/on-line-packed-magnetic-in-tube-solid-phase-microextraction-of-acidic-tc0sU8QOKD
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Chemistry; Nanochemistry; Nanotechnology; Characterization and Evaluation of Materials; Analytical Chemistry; Microengineering
ISSN
0026-3672
eISSN
1436-5073
D.O.I.
10.1007/s00604-018-2716-7
Publisher site
See Article on Publisher Site

Abstract

The authors describe a 3-component nanoparticle system composed of a silica-coated magnetite (Fe3O4) core and a layered double (Cu-Cr) hydroxide nanoplatelet shell. The sorbent has a high anion exchange capacity for extraction anionic species. A simple online system, referred to as "on-line packed magnetic-in-tube solid phase microextraction" was designed. The nanoparticles were placed in a stainless steel cartridge via dry packing. The cartridge was then applied to the preconcentration acidic drugs including naproxen and indomethacin from urine and plasma. Extraction and desorption times, pH values of the sample solution and flow rates of sample solution and eluent were optimized. Analytes were then quantified by HPLC with UV detection. Under optimal conditions, the limits of detection range from 70 to 800 ng L−1, with linear responses from 0.1–500 μg L−1 (water samples), 0.6–500 μg L−1 (spiked urine), and 0.9–500 μg L−1 (spiked plasma). The inter- and intra-assay precisions (RSDs, for n = 5) are in the range of 2.2–5.4%, 2.8–4.9%, and 2.0–5.2% at concentration levels of 5, 25 and 50 μg L−1, respectively. The method was applied to the analysis of the drugs in spiked human urine and plasma, and good results were achieved.

Journal

Microchimica ActaSpringer Journals

Published: Feb 22, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off