Olanzapine/risperidone Reactions 1680, p267 - 2 Dec 2017 Extrapyramidal side effects: case report A 48-year-old man developed extrapyramidal side effects during treatment with olanzapine and risperidone. The man had a history of bilateral otitis media and had undergone bilateral myringoplasty at the age of 18 years. At the age of 38 years, he presented with psychiatric symptoms, for which he received risperidone. Following 9.5 years of this treatment, his symptoms worsened for several times due to the discontinuation of treatment. However, after commencing individual treatment with olanzapine 20mg and risperidone 8mg for three weeks each [route not stated], the symptoms persisted. He developed extrapyramidal side effects [duration of treatment to reaction onset and outcome not stated]. The man’s antipsychotic therapy was switched to trifluoperazine and he received trihexyphenidyl to manage extrapyramidal side effects. Author comment: ’’Despite individual treatment with risperidone 8 mg and olanzapine 20 mg for 3weeks each, the symptoms did not improve. However, within 2 weeks of switching to trifluoperazine 30 mg and trihexyphenidyl 4–6 mg (to manage extrapyramidal side effects), his psychotic symptoms improved completely’’. Jain S, et al. Improvement of tinnitus with trifluoperazine in a patient with psychosis and ear disease. Asian Journal of Psychiatry 30: 177-178, Dec 2017. Available from: URL: http://doi.org/10.1016/j.ajp.2017.10.027 - India 803284172 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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