Reactions 1704, p286 - 2 Jun 2018
Hypothermia: case report
An 83-year-old woman developed hypothermia during
treatment with olanzapine for generalised anxiety disorder
[route not stated].
The woman was transferred to the emergency room with a
decreased level of consciousness and Glasgow coma scale
score of 7. She was responsive and was able to localise pain.
She was noted to have bradycardia. Her BP was 80/150mm Hg
and respiratory rate was 26 /minute. Her physical examination
showed anal temperature of 30.9°C. At the time of admission,
an ECG revealed sinus bradycardia with J waves. It was
reported that she was suffering from generalised anxiety
disorder for the last 2 years and was prescribed olanzapine
7.5mg daily for two years. On the days before the event, she
experienced a cognitive impairment with heat intolerance and
her olanzapine dose was reduced to 5mg daily. Based on the
clinical findings, her body temperature and ECG findings, she
was diagnosed with hypothermia associated with the use of
The woman was rewarmed gradually with warmed sodium
chloride [saline] solutions, washing with warm fluids
through nasogastric tube and urinary catheter, and external
heating by thermal blanket. Treatment with olanzapine was
stopped and she regained consciousness after 18 hours.
Following clinical improvement, her body temperature was
measured as 37.8°C and there was an overall improvement in
her neurological conditions.
Author comment: "Based on the findings in our patient
and from the data from literature, we hypothesize that the
patient developed hypothermia due to olanzapine."
Monti M, et al. Olanzapine-associated hypothermia: A case report of a rare event.
Italian Journal of Medicine 12: 67-69, No. 1, Jan 2018 - Italy
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved