Of Salamanders and Spiny Mice: Common Features of Regeneration and Stem Cells

Of Salamanders and Spiny Mice: Common Features of Regeneration and Stem Cells Curr Stem Cell Rep (2017) 3:164–171 DOI 10.1007/s40778-017-0086-4 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) Of Salamanders and Spiny Mice: Common Features of Regeneration and Stem Cells Malcolm Maden Published online: 15 July 2017 Springer International Publishing AG 2017 Abstract Introduction Purpose of Review This review identifies the salient cellular and molecular features of regeneration of the skin and limbs of Axolotls and newts, which belong to the order Urodela (tailed salamanders to see whether any of these features are in com- amphibians), are the champions of vertebrate regeneration. mon with recent reports on the spiny mouse (Acomys), a mam- They can regenerate virtually every tissue and organ that has mal with some remarkable regenerative behavior. Other re- been tested—the lens, retina, lower jaw, forebrain, midbrain, ports of mammalian regeneration are also highlighted. spinal cord, peripheral nerves, optic nerve, limb, tail, heart, Recent Findings Mammals have classically been regarded as lung, pancreas, liver, and skin. The regenerative ability of non-regenerating, but the regeneration of several embryonic the tail was first noted long ago by Aristotle and, along with and post-natal tissues as well as reports of adult skin and ear limb and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Stem Cell Reports Springer Journals

Of Salamanders and Spiny Mice: Common Features of Regeneration and Stem Cells

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Life Sciences; Cell Biology; Stem Cells
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