Arch Virol (2002) 147: 841–847
Odocoileus hemionus deer adenovirus is related
to the members of Atadenovirus genus
, A. Bout
, L. W. Woods
H. D. Lehmkuhl
, and M. J. E. Havenga
Crucell Holland BV,Leiden,The Netherlands
California Veterinary Diagnostic Laboratory System,School of Veterinary Medicine,
University of California,Davis,California,U.S.A.
Respiratory and Neurologic Disease Research Unit,National Animal Disease Center,
Agricultural Research Service,US Department of Agriculture,Ames,Iowa,U.S.A.
Accepted November 22,2001
Summary. The Odocoileus hemionus deer adenovirus (OdAdV-1) causes sys-
temic and local vasculitis and proves extremely lethal for mule deer. To char-
acterize the virus,part of the genome ﬂanking the ﬁber gene was cloned and
sequenced. The sequence revealed two open-reading frames that mapped to pVIII
hexon-associatedproteinprecursor andﬁberprotein ofseveralother adenoviruses.
The highest amino acid homology for pVIII and ﬁber was found with the members
of the proposed Atadenovirus genus: ovine adenovirus isolate 287 (OAdV-287),
bovine adenovirus 4 (BAdV-4) and duck adenovirus 1 (DAdV-1). The homol-
ogy with bovine adenovirus type 3 (BAdV-3) proved low. The E3 region was not
found between the gene for pVIII and ﬁber. These data suggest that OdAdV-1 is
a member of the Atadenovirus genus.
In 1993,thousands of mule deer (Odocoileus hemionus) died in California of
severe vasculitis. Detailed pathology demonstrated the presence of an adenovirus
that could be isolated from primary cultures of black-tailed deer (Odocoileus
hemionus columbianus) pulmonary artery endothelial cells . Since the disease
could be experimentally reproduced in black-tailed deer fawns after inoculation
with Odocoileus hemionus deer (OdAdV-1) adenovirus  the cause of the
Present address:VIDO,Universityof Saskatchewan,Saskatoon,Saskatchewan,Canada.