Drug Saf (2017) 40:823–834 DOI 10.1007/s40264-017-0551-0 ORIGINAL RESEARCH ARTICLE Occurrence of Multiple Sclerosis After Drug Exposure: Insights From Evidence Mapping 1 1 2 • • • Ippazio Cosimo Antonazzo Emanuel Raschi Luca Vignatelli 2,3 4,5 2 1 • • • • Elisa Baldin Trond Riise Roberto D’Alessandro Fabrizio De Ponti Elisabetta Poluzzi Published online: 9 June 2017 Springer International Publishing Switzerland 2017 Abstract reviews): 30 case reports and case series, 24 longitudinal Introduction The role of drugs in the occurrence of multiple studies and four randomized controlled trials. Seven longitu- sclerosis (MS) is perceived to be insufﬁciently investigated. dinal studies had good (at least 7 out of 9) quality scores, Objective The aim of this study was to map and assess the whereas case reports/case series presented several limitations. evidence on MS occurrence after drug exposure, in order to Half of included articles focused on immunomodulatory drugs identify possible signals of causal association. (etanercept, inﬂiximab and adalimumab), especially in case Methods A search strategy was performed in MEDLINE reports/series, suggesting an association with MS occurrence. and Embase as of July 2016; references consistent with the Contraceptives and antibacterials were investigated in some aim of the study were analysed to
Drug Safety – Springer Journals
Published: Jun 9, 2017
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