Purpose of Review This short review is aimed at presenting the most recent literature linking obstructive sleep apnea (OSA) with metabolic risk. Recent Findings In the last decades, substantial evidence derived from experimental, translational, and clinical studies has supported the possibility that OSA predisposes to cardiovascular diseases via activation and propagation of multiple pathophys- iological pathways. While initial studies focused on the hemodynamic effects of OSA, further studies indicated that the compo- nents of OSA (especially intermittent hypoxia) also promote metabolic deregulation, including insulin resistance, impaired lipoprotein clearance, and dyslipidemia. Summary This review indicates that the precise effects of chronic intermittent hypoxia and the relative impact of sleep fragmen- tation on glucose and lipid metabolism still require further studies as well as the impact of effective OSA treatment. Personalized medicine devoting to explore potential biomarkers that predicts metabolic risk may help to prevent cardiovascular disease in patients with OSA. . . . . . Keywords Obstructive sleep apnea Dyslipidemia Glucose metabolism Insulin resistance Lipid metabolism Cardiovascular disease Introduction Until recently, OSA was considered a mere epiphenome- non of obesity, and all harmful effects of obesity were Obstructive sleep apnea (OSA) is a common sleep distur- attributed to the increased
Current Sleep Medicine Reports – Springer Journals
Published: Apr 21, 2018
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