O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian

O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type. Herein, we review the impact of altered O-GlcNAcylation in breast, ovarian and uterine cancers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bioenergetics and Biomembranes Springer Journals

O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Chemistry; Bioorganic Chemistry; Biochemistry, general; Animal Anatomy / Morphology / Histology; Animal Biochemistry; Organic Chemistry
ISSN
0145-479X
eISSN
1573-6881
D.O.I.
10.1007/s10863-017-9730-z
Publisher site
See Article on Publisher Site

Abstract

O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type. Herein, we review the impact of altered O-GlcNAcylation in breast, ovarian and uterine cancers.

Journal

Journal of Bioenergetics and BiomembranesSpringer Journals

Published: Nov 10, 2017

References

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