Nucleotide Sequences of Long Terminal Repeats of the Human Endogenous Retroviruses (LTR HERV-K) on the Short Arm of Chromosome 7: Identification, Map Locations, and Transcriptional Activity

Nucleotide Sequences of Long Terminal Repeats of the Human Endogenous Retroviruses (LTR HERV-K)... Six clones containing long terminal repeat (LTR) sequences of human endogenous retrovirus of the HERV-K family were found in the YAC library (1200 kb) of the short arm of human chromosome 7. The sequence sizes of the three clones corresponded to the full-size LTR (969 bp). The LTR localization was determined using FISH and verified by comparison with the GenBank database. All three DNA fragments containing solitary LTRs were transcribed in normal germline cells (testicular parenchyma tissue). The differences in the expression of these clones in the germline tumor cells (seminoma) were observed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Nucleotide Sequences of Long Terminal Repeats of the Human Endogenous Retroviruses (LTR HERV-K) on the Short Arm of Chromosome 7: Identification, Map Locations, and Transcriptional Activity

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Publisher
Springer Journals
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1023744019585
Publisher site
See Article on Publisher Site

Abstract

Six clones containing long terminal repeat (LTR) sequences of human endogenous retrovirus of the HERV-K family were found in the YAC library (1200 kb) of the short arm of human chromosome 7. The sequence sizes of the three clones corresponded to the full-size LTR (969 bp). The LTR localization was determined using FISH and verified by comparison with the GenBank database. All three DNA fragments containing solitary LTRs were transcribed in normal germline cells (testicular parenchyma tissue). The differences in the expression of these clones in the germline tumor cells (seminoma) were observed.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 7, 2004

References

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