Access the full text.
Sign up today, get DeepDyve free for 14 days.
Yaping Chen, T. Maguire, R. Marks (1996)
Demonstration of binding of dengue virus envelope protein to target cellsJournal of Virology, 70
J. Donnelly, K. Berry, J. Ulmer (2003)
Technical and regulatory hurdles for DNA vaccines.International journal for parasitology, 33 5-6
D. Vaughn (2000)
Invited commentary: Dengue lessons from Cuba.American journal of epidemiology, 152 9
M. Muné, R. Rodríguez, R. Ramírez, Y. Soto, B. Sierra, R. Roche, G. Márquez, J. García, G. Guillén, M. Guzmán (2003)
Carboxy-terminally truncated Dengue 4 virus envelope glycoprotein expressed in Pichia pastoris induced neutralizing antibodies and resistance to Dengue 4 virus challenge in miceArchives of Virology, 148
J. Mongkolsapaya, T. Duangchinda, W. Dejnirattisai, Sirijitt Vasanawathana, Panisadee Avirutnan, Aroonroong Jairungsri, Nuanpan Khemnu, N. Tangthawornchaikul, P. Chotiyarnwong, Kanokwan Sae-Jang, Michaela Koch, Y. Jones, A. McMichael, Xiaoning Xu, P. Malasit, G. Screaton (2006)
T Cell Responses in Dengue Hemorrhagic Fever: Are Cross-Reactive T Cells Suboptimal?1The Journal of Immunology, 176
Rajarshi Ghosh (2011)
A Summary of
E. Iglesias, R. Thompson, Y. Carrazana, Y. Lobaina, D. García, Jorge Sanchez, José García, O. Cruz, E. Brown, Alejandro Martin, V. Muzio, J. Aguilar (2006)
Coinoculation with hepatitis B surface and core antigen promotes a Th1 immune response to a multiepitopic protein of HIV‐1Immunology and Cell Biology, 84
Antonio Pérez, F. Dickinson, Z. Cinza, A. Ruíz, T. Serrano, J. Sosa, S. González, Yainelis Gutiérrez, C. Nazábal, Oderay Gutiérrez, D. Guzmán, M. Díaz, M. Delgado, Evelín Caballero, G. Sardiñas, A. Álvarez, Alejandro Martin, G. Guillén, Ricardo Silva (2001)
Safety and preliminary immunogenicity of the recombinant outer membrane protein P64k of Neisseria meningitidis in human volunteersBiotechnology and Applied Biochemistry, 34
L. Hermida, R. Rodríguez, L. Lazo, Ricardo Silva, A. Zulueta, G. Chinea, C. López, M. Guzmán, G. Guillén (2004)
A dengue-2 Envelope fragment inserted within the structure of the P64k meningococcal protein carrier enables a functional immune response against the virus in mice.Journal of virological methods, 115 1
S. Gagnon, Weilan Zeng, I. Kurane, F. Ennis (1996)
Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clonesJournal of Virology, 70
A. Zulueta, Jorge Martín, L. Hermida, M. Álvarez, I. Valdes, Irina Prado, G. Chinea, D. Rosario, G. Guillén, M. Guzmán (2006)
Amino acid changes in the recombinant Dengue 3 Envelope domain III determine its antigenicity and immunogenicity in mice.Virus research, 121 1
Petra Riedl, D. Stober, C. Oehninger, K. Melber, J. Reimann, R. Schirmbeck (2002)
Priming Th1 Immunity to Viral Core Particles Is Facilitated by Trace Amounts of RNA Bound to Its Arginine-Rich Domain1The Journal of Immunology, 168
D. Clarke, J. Casals (1958)
Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.The American journal of tropical medicine and hygiene, 7 5
I. Valdes, L. Hermida, Jorge Martín, T. Menéndez, L. Gil, L. Lazo, J. Castro, O. Niebla, C. López, Lidice Bernardo, Jorge Sanchez, Y. Romero, R. Martínez, M. Guzmán, G. Guillén (2009)
Immunological evaluation in nonhuman primates of formulations based on the chimeric protein P64k-domain III of dengue 2 and two components of Neisseria meningitidis.Vaccine, 27 7
L. Gil, C. López, A. Blanco, L. Lazo, Jorge Martín, I. Valdes, Y. Romero, Yassel Figueroa, G. Guillén, L. Hermida (2009)
The cellular immune response plays an important role in protecting against dengue virus in the mouse encephalitis model.Viral immunology, 22 1
L. Lazo, A. Zulueta, L. Hermida, A. Blanco, Joaquín Sánchez, I. Valdes, L. Gil, C. López, Y. Romero, M. Guzmán, G. Guillén (2009)
Dengue‐4 envelope domain III fused twice within the meningococcal P64k protein carrier induces partial protection in miceBiotechnology and Applied Biochemistry, 52
R. Edelman, S. Wasserman, S. Bodison, R. Putnak, K. Eckels, D. Tang, N. Kanesa-thasan, D. Vaughn, B. Innis, Wellington Sun (2003)
Phase I trial of 16 formulations of a tetravalent live-attenuated dengue vaccine.The American journal of tropical medicine and hygiene, 69 6 Suppl
R. Sugrue, Jianlin Fu, Josephine Howe, Y. Chan (1997)
Expression of the dengue virus structural proteins in Pichia pastoris leads to the generation of virus-like particles.The Journal of general virology, 78 ( Pt 8)
L. Álvarez-Lajonchere, Marleny González, J. Alvarez-Obregón, Ivis Guerra, A. Viña, N. Acosta-Rivero, A. Musacchio, J. Morales, S. Dueñas-Carrera (2006)
Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co‐delivered DNA vaccine encoding HCV structural antigens in miceBiotechnology and Applied Biochemistry, 44
J. Putnak, Rafael Barrera, T. Burgess, Jorge Pardo, Francis Dessy, D. Gheysen, Y. Lobet, S. Green, T. Endy, Stephen Thomas, K. Eckels, B. Innis, Wellington Sun (2008)
Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies.The American journal of tropical medicine and hygiene, 79 1
E. Grgacic, David Anderson (2006)
Virus-like particles: Passport to immune recognitionMethods (San Diego, Calif.), 40
T. Storni, C. Ruedl, K. Schwarz, R. Schwendener, W. Renner, M. Bachmann (2004)
Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side EffectsThe Journal of Immunology, 172
L. Gil, C. López, L. Lazo, I. Valdes, E. Marcos, Ruby Alonso, Ailyn Gambe, Jorge Martín, Y. Romero, M. Guzmán, G. Guillén, L. Hermida (2009)
Recombinant nucleocapsid-like particles from dengue-2 virus induce protective CD4+ and CD8+ cells against viral encephalitis in mice.International immunology, 21 10
F. Takeshita, C. Leifer, I. Gursel, K. Ishii, S. Takeshita, M. Gursel, D. Klinman (2001)
Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells1The Journal of Immunology, 167
Jean‐Rémy Sadeyen, S. Tourne, Marina Shkreli, P. Sizaret, P. Coursaget (2003)
Insertion of a foreign sequence on capsid surface loops of human papillomavirus type 16 virus-like particles reduces their capacity to induce neutralizing antibodies and delineates a conformational neutralizing epitope.Virology, 309 1
S. Gagnon, F. Ennis, A. Rothman (1999)
Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4+ Cytotoxic T-Lymphocyte ClonesJournal of Virology, 73
Sang-Moo Kang, Q. Yao, Lizheng Guo, R. Compans (2003)
Mucosal Immunization with Virus-Like Particles of Simian Immunodeficiency Virus Conjugated with Cholera Toxin Subunit BJournal of Virology, 77
M. Simmons, Gerald Murphy, Curtis Hayes (2001)
Short report: Antibody responses of mice immunized with a tetravalent dengue recombinant protein subunit vaccine.The American journal of tropical medicine and hygiene, 65 2
C. Tacket, M. Sztein, G. Losonsky, S. Wasserman, M. Estes (2003)
Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers.Clinical immunology, 108 3
L. Lazo, L. Hermida, A. Zulueta, Jorge Sanchez, C. López, Ricardo Silva, G. Guillén, M. Guzmán (2007)
A recombinant capsid protein from Dengue-2 induces protection in mice against homologous virus.Vaccine, 25 6
H. Kawano, V. Rostapshov, L. Rosen, Ching-Juh Lai (1993)
Genetic determinants of dengue type 4 virus neurovirulence for miceJournal of Virology, 67
M. Mangada, A. Rothman (2005)
Altered Cytokine Responses of Dengue-Specific CD4+ T Cells to Heterologous Serotypes 1The Journal of Immunology, 175
R. Most, K. Murali-Krishna, R. Ahmed, J. Strauss (2000)
Chimeric Yellow Fever/Dengue Virus as a Candidate Dengue Vaccine: Quantitation of the Dengue Virus-Specific CD8 T-Cell ResponseJournal of Virology, 74
Lidice Bernardo, A. Izquierdo, M. Álvarez, D. Rosario, Irina Prado, C. López, R. Martínez, J. Castro, E. Santana, L. Hermida, G. Guillén, M. Guzmán (2008)
Immunogenicity and protective efficacy of a recombinant fusion protein containing the domain III of the dengue 1 envelope protein in non-human primates.Antiviral research, 80 2
P. Pushko, T. Tumpey, Fang-tian Bu, J. Knell, Robin Robinson, Gale Smith (2005)
Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice.Vaccine, 23 50
J. Roehrig (2003)
Antigenic structure of flavivirus proteins.Advances in virus research, 59
C. López, L. Gil, L. Lazo, I. Menéndez, E. Marcos, Jorge Sanchez, I. Valdes, V. Falcón, M. Rosa, G. Márquez, G. Guillén, L. Hermida (2009)
In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virusArchives of Virology, 154
R. Edelman (2007)
Dengue vaccines approach the finish line.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 45 Suppl 1
A. Zulueta, L. Hermida, L. Lazo, I. Valdes, R. Rodríguez, C. López, Ricardo Silva, D. Rosario, Jorge Martín, M. Guzmán, G. Guillén (2003)
The fusion site of envelope fragments from each serotype of Dengue virus in the P64k protein, influence some parameters of the resulting chimeric constructs.Biochemical and biophysical research communications, 308 3
González, Álvarez, Caballero, Viña, Guillén, Silva (2000)
P64k Meningococcal Protein as Immunological Carrier for Weak ImmunogensScandinavian Journal of Immunology, 52
Kelly Warfield, C. Bosio, Brent Welcher, E. Deal, M. Mohamadzadeh, A. Schmaljohn, M. Aman, S. Bavari (2003)
Ebola virus-like particles protect from lethal Ebola virus infectionProceedings of the National Academy of Sciences of the United States of America, 100
M. Saini, S. Vrati (2003)
A Japanese Encephalitis Virus Peptide Present on Johnson Grass Mosaic Virus-Like Particles Induces Virus-Neutralizing Antibodies and Protects Mice against Lethal ChallengeJournal of Virology, 77
R. Most, K. Murali-Krishna, R. Ahmed (2003)
Prolonged presence of effector‐memory CD8 T cells in the central nervous system after dengue virus encephalitisInternational Immunology, 15
David Morens, Scott Halstead, Patricia Repik, Ravithat Putvatana, '. Raybourne (1985)
Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralizationJournal of Clinical Microbiology, 22
J. Aguilar, Y. Lobaina, V. Muzio, D. García, E. Pentón, Enrique Iglesias, D. Pichardo, Dioslaida Urquiza, D. Rodríguez, Diego Silva, Nikolai Petrovsky, Gerardo Guillén (2004)
Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigenImmunology and Cell Biology, 82
Yao-Chi Chung, M. Ho, Jaw-Chin Wu, Wei-Jheng Chen, Jen-Huang Huang, S. Chou, Yu-Chen Hu (2008)
Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge.Vaccine, 26 15
H. Chaung (2006)
CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy.International immunopharmacology, 6 10
M. Lobigs, A. Müllbacher, Eva Lee (2004)
Evidence that a mechanism for efficient flavivirus budding upregulates MHC class IImmunology and Cell Biology, 82
RJ Kuhn, W Zhang, MG Rossmann, SV Pletnev, J Corver, E Lenches, CT Jones, S Mukhopadhyay, PR Chipman, EG Strauss, TS Baker, JH Strauss (2002)
Structure of dengue virus: implications for flavivirus organization, maturation, and fusionCell, 108
In this study, we evaluate in mice a novel formulation containing nucleocapsid-like particles of dengue-2 virus (recNLP) co-immunized with a chimeric protein composed of the dengue-4 envelope domain III fused twice within the meningococcal P64k protein of Neisseria meningitidis (PD24). The animals receiving the PD24–recNLP mixture showed the highest levels of antiviral antibodies. Similar results were obtained for IFNγ secretion levels, indicating a functional Th1 cellular response. Consistently, the percentage of mice surviving after viral challenge was significantly higher for those immunized with the mixture than for those inoculated with PD24 protein alone. In addition, in vivo depletion experiments demonstrated the decisive role of CD4 + and CD8 + cells in the protection conferred by immunization with PD24–recNLP. In conclusion, this report demonstrates for the first time the adjuvant capacity of dengue-2 virus recNLP. Additionally, the evidence presented highlights the potential of these particles for enhancing the immune response against heterologous recombinant proteins.
Archives of Virology – Springer Journals
Published: Oct 1, 2010
Access the full text.
Sign up today, get DeepDyve free for 14 days.