Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase

Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase Plant Mol Biol (2016) 92:235–248 DOI 10.1007/s11103-016-0509-0 Novel thidiazuron-derived inhibitors of cytokinin ogenaseoxidase/dehydr 1,2,3 4 4 1,2 oslavJar Nisler  · David Kopečný  · Radka Končitíková · Marek Zatloukal · 1,5 5,6 7 8 Václav Bazgier  · Karel Berka  · David Zalabák  · Pierre Briozzo · 1 1,2 oslavMir Strnad  · Lukáš Spíchal Received: 21 April 2016 / Accepted: 29 June 2016 / Published online: 15 July 2016 © Springer Science Business Media Dordrecht 2016 Abstract of cytokinins and their fects ef in plants. e W used in silico Key message wo new T TDZ derivatives (HETDZ and modeling to design, synthesize and characterize twenty new 3FMTDZ) are very potent inhibitors of CKX and are TDZ derivatives with improved inhibitory properties. wo T omising candidates for pr in vivo studies. compounds, namely 1-[1,2,3]thiadiazol-5-yl-3-(3-trifluo - Abstract Cytokinin hormones regulate a wide range romethoxy-phenyl)urea (3FMTDZ) and 1-[2-(2-hydroxy- of essential processes in plants. Thidiazuron ( N -phenyl- ethyl)phenyl]-3-(1,2,3-thiadiazol-5-yl)urea (HETDZ), dis- N ′-1,2,3-thiadiazol-5-yl urea, TDZ), formerly registered as played up to 15-fold lower IC values compared with TDZ a cotton defoliant, is a well known inhibitor of cytokinin for AtCKX2 from Arabidopsis thaliana and ZmCKX1 and oxidase/dehydrogenase (CKX), an enzyme catalyzing the ZmCKX4a from Zea mays . Binding modes of 3FMTDZ and degradation of cytokinins. TDZ thus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plant Molecular Biology Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Life Sciences; Plant Sciences; Biochemistry, general; Plant Pathology
ISSN
0167-4412
eISSN
1573-5028
D.O.I.
10.1007/s11103-016-0509-0
Publisher site
See Article on Publisher Site

Abstract

Plant Mol Biol (2016) 92:235–248 DOI 10.1007/s11103-016-0509-0 Novel thidiazuron-derived inhibitors of cytokinin ogenaseoxidase/dehydr 1,2,3 4 4 1,2 oslavJar Nisler  · David Kopečný  · Radka Končitíková · Marek Zatloukal · 1,5 5,6 7 8 Václav Bazgier  · Karel Berka  · David Zalabák  · Pierre Briozzo · 1 1,2 oslavMir Strnad  · Lukáš Spíchal Received: 21 April 2016 / Accepted: 29 June 2016 / Published online: 15 July 2016 © Springer Science Business Media Dordrecht 2016 Abstract of cytokinins and their fects ef in plants. e W used in silico Key message wo new T TDZ derivatives (HETDZ and modeling to design, synthesize and characterize twenty new 3FMTDZ) are very potent inhibitors of CKX and are TDZ derivatives with improved inhibitory properties. wo T omising candidates for pr in vivo studies. compounds, namely 1-[1,2,3]thiadiazol-5-yl-3-(3-trifluo - Abstract Cytokinin hormones regulate a wide range romethoxy-phenyl)urea (3FMTDZ) and 1-[2-(2-hydroxy- of essential processes in plants. Thidiazuron ( N -phenyl- ethyl)phenyl]-3-(1,2,3-thiadiazol-5-yl)urea (HETDZ), dis- N ′-1,2,3-thiadiazol-5-yl urea, TDZ), formerly registered as played up to 15-fold lower IC values compared with TDZ a cotton defoliant, is a well known inhibitor of cytokinin for AtCKX2 from Arabidopsis thaliana and ZmCKX1 and oxidase/dehydrogenase (CKX), an enzyme catalyzing the ZmCKX4a from Zea mays . Binding modes of 3FMTDZ and degradation of cytokinins. TDZ thus

Journal

Plant Molecular BiologySpringer Journals

Published: Jul 15, 2016

References

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