J Mol Med (2017) 95:899–903 DOI 10.1007/s00109-017-1574-9 EDITORIAL Novel therapeutic concepts for inflammatory bowel disease—from bench to bedside 1 2 3 Viola Neudecker & Sean P. Colgan & Holger K. Eltzschig Published online: 5 August 2017 Springer-Verlag GmbH Germany 2017 In this special issue of the Journal of Molecular Medicine,we immune responses can result in loss of barrier function and are privileged to publish review articles on the latest advance- invasion or translocation of luminal microorganisms. In turn, ments in mucosal inflammatory disease research. Four labo- this constellation can trigger systemic inflammation and sep- ratories focused on translational research in the field of muco- sis, and might even result in multiple organ dysfunctions. Loss of barrier function also represents the grounds on which mu- sal inflammation, in particular inflammatory bowel disease (IBD), outline the most recent achievements in the progress cosal inflammatory disease might arise. In the two major mu- of translating research findings into therapeutic innovation cosal organs, the intestinal and pulmonary mucosa, inflamma- (Fig. 1). tory bowel disease (IBD), including Crohn’s disease (CD) and Epithelial cells lining tissue surfaces represent multifunc- ulcerative colitis (UC) as well as acute lung injury, constitute tional barriers separating the body from
Journal of Molecular Medicine – Springer Journals
Published: Aug 5, 2017
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