J Mater Sci: Mater Med (2018) 29:1 DOI 10.1007/s10856-017-6005-5 TISSUE ENGINEERING CONSTRUCTS AND CELL SUBSTRATES Original Research Novel poss reinforced chitosan composite membranes for guided bone tissue regeneration 1 2 Sedef Tamburaci Funda Tihminlioglu Received: 23 December 2016 / Accepted: 17 November 2017 / Published online: 1 December 2017 © Springer Science+Business Media, LLC, part of Springer Nature 2017 Abstract In this study, novel composites membranes ALP activity results showed that POSS incorporation sig- composed of chitosan matrix and polyhedral oligomeric niﬁcantly increased the ALP activity of Saos-2 cells cul- silsesquioxanes (POSS) were fabricated by solvent casting tured on chitosan membranes. This novel composite method. The effect of POSS loading on the mechanical, membranes with tunable properties could be considered as a morphological, chemical, thermal and surface properties, potential candidate for guided bone regeneration and cytocompatibility of composite membranes were applications. investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectro- Graphical abstract scopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST- 1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS nanoﬁller to the chitosan matrix increased the surface
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Dec 1, 2017
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