Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and in vivo evaluation

Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and... efficient, stable, chemically crosslinked polymeric system that have pH responsive behaviour and can effectively release 5-FU in a controlled manner. Furthermore it can target colonic cancer minimizing the side effects of in vivo chemotherapy via 5-FU. Swelling and drug release studies were performed to evaluate its in vitro release behaviour. Hydrogels were also characterized by FTIR, SEM and DSC. In vitro cytocompatibility and cytotoxicity of the hydrogels were determined by MTT assay using HeLa cells. Devel- oped hydrogels were then administered to rabbits orally to evaluate its pharmacokinetic behaviour in vivo. Maximum swelling, drug loading and release were observed at pH 7.4. Similarly maximum absorption was achieved at pH 7.4 in rabbits. It is concluded that CMC-co-poly(AA) have a great potential to be used for controlled drug delivery and colonic targeting for the delivery for various anticancer drugs. 1 Introduction Electronic supplementary material The online version of this article Predominantly, the pharmaceutical researchers have been (doi:10.1007/s10856-017-5952-1) contains supplementary material, focusing to discover the novel drugs and unusual drug which is available to authorized users. administration systems, out of which controlled release * Muhammad Sohail systems have great importance. Among the diverse cate- gories of polymeric systems employed by Journal of Materials Science: Materials in Medicine Springer Journals

Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and in vivo evaluation

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Springer US
Copyright © 2017 by Springer Science+Business Media, LLC
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
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