Novel molecular alterations in the ORF 2 capsid gene of hepatitis E virus in patients with acute liver failure in North India

Novel molecular alterations in the ORF 2 capsid gene of hepatitis E virus in patients with acute... Hepatitis E virus (HEV) is evolving as a major global threat to public health, including in developed countries. We partially sequenced the ORF 2 capsid protein genes of HEV genomes from patients with acute liver failure, including pregnant women in the northern part of India. Five unique synonymous substitutions and one non-synonymous substitution, along with a novel mutation, P259S, in the capsid gene, were identified that might be associated with the poor outcome in the patients. Phylogenetic analysis revealed that the isolates belonged to genotype 1 with subtype 1a. The significance of these findings for disease pathogenicity needs to be investigated further. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Novel molecular alterations in the ORF 2 capsid gene of hepatitis E virus in patients with acute liver failure in North India

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2198-9
Publisher site
See Article on Publisher Site

References

  • Hepatitis E virus: current concepts and future perspectives
    Dalton, HR; Pas, SD; Madden, RG; Eijk, AA
  • Aetiology and clinical course and outcome of sporadic acute viral hepatitis in pregnancy
    Khuroo, MS; Kamili, S

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