Access the full text.
Sign up today, get DeepDyve free for 14 days.
AF Mukeriya, DG Zaridze (2010)
Epidemiology and prophylaxis of lung cancerVestn. Ross. Oncol. Nauchn. Tsentr im. N.N. Blokhina Ross. Akad. Med. Nauk, 21
PA Jones (2012)
Functions of DNA methylation: islands, start sites, gene bodies and beyondNat. Rev. Genet., 13
C Yang, J Cai, Q Wang (2012)
Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1Gynecol. Oncol., 124
KH Lee, C Lotterman, C Karikari (2009)
Epigenetic silencing of microRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancerPancreatology, 9
Y Li, Q Jiang, N Xia (2012)
J. Int. Med. Res.
AA Ponomareva, EYu Rykova, NV Cherdyntseva (2011)
Molecular and genetic markers in diagnostics of lung cancerMol. Biol. (Moscow), 45
F Sato, S Tsuchiya, SJ Meltzer (2011)
microRNAs and epigeneticsFEBS J., 278
L Zhang, PS Sullivan, JC Goodman (2011)
microRNA-1258 suppresses breast cancer brain metastasis by targeting heparanaseCancer Res., 71
Y Zhang, LX Yan, QN Wu (2011)
miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancerCancer Res., 71
T Kunej, I Godnic, J Ferdin (2011)
Epigenetic regulation of microRNAs in cancer: an integrated review of literatureMutat. Res., 717
X Zhu, Y Li, H Shen (2013)
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6FEBS Lett., 587
J Qi, D Mu (2012)
microRNAs and lung cancers: from pathogenesis to clinical implicationsFront. Med., 6
DS Khodyrev, IV Pronina, SV Rykov (2012)
Involvement of methylation of group of miRNA genes in regulation of expression of RAR-beta2 and NKIRAS1 target genes in lung cancerMol. Biol. (Moscow), 46
F Balaguer, A Link, JJ Lozano (2010)
Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesisCancer Res., 70
S Dacic, L Kelly, Y Shuai (2010)
miRNA expression profiling of lung adenocarcinomas: correlation with mutational statusMod. Pathol., 23
M Kato, FJ Slack (2008)
microRNAs: small molecules with big roles—C. elegans to human cancerBiol. Cell, 100
H Liu, X Chen, W Gao (2012)
The expression of heparanase and microRNA-1258 in human non-small cell lung cancerTumour Biol., 33
L Friboulet, D Barrios-Gonzales, F Commo (2011)
Molecular characteristics of ERCC1-negative versus ERCC1-positive tumors in resected NSCLCClin. Cancer Res., 17
HS Hsu, TP Chen, CH Hung (2007)
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasmaCancer, 110
MicroRNAs play an important role in the regulation of expression of many genes and are involved in carcinogenesis. The regulation of miRNA gene expression can involve the methylation of promoter CpG islands. In this work, the methylation of six miRNA genes (mir-107, mir-125b-1, mir-130b, mir-137, mir-375, and mir-1258) in non-small-cell lung cancer (NSCLC) was studied for the first time by methylation-specific PCR using a representative set of specimens (39 cases). Four new genes (mir-125b-1, mir-137, mir-375, and mir-1258) methylated in primary NSCLC tumors were identified with frequencies of 56, 31, 56, and 36%, respectively. The frequencies of miRNA promoter methylation in DNA of tumors and histologically normal tissues differed significantly (P ≤ 0.05 by Fisher’s test). In lung tissues of 20 donors without a history of cancer, these genes were only methylated in a few cases. It was also shown that the previously unstudied promoter CpG islands of mir-107 and mir-130b were not methylated in NSCLC. The frequencies of mir-125b-1 and mir-137 methylation were shown for the first time to correlate with NSCLC progression (clinical stage and metastasis).
Russian Journal of Genetics – Springer Journals
Published: Jul 12, 2013
Access the full text.
Sign up today, get DeepDyve free for 14 days.