Novel memory mutants in Drosophila: Behavioral characteristics of the P-Insertional mutant Ent2 P124

Novel memory mutants in Drosophila: Behavioral characteristics of the P-Insertional mutant Ent2 P124 The Drosophila mutant P124, carrying insertion of P (lacW) vector in the second chromosome on the background of the w mutation in the X chromosome, was previously isolated as showing memory deficiency after courtship conditioning. Here we report additional features of the mutant phenotype: (1) abnormal adaptation to darklight transition; (2) impaired perception by males of nuances of visual image of a female, specifically, of her fine movements such as preening and ovipositor extrusion; (3) subnormal performance index after odor-shock conditioning. These abnormalities are not related to a deficit of the eye screening pigments because they are also revealed on the background of the normal w + allele in the X chromosome. The visual and cognitive impairments are independent pleiotropic effects of the mutation. The mutation is caused by insertion of the P vector 12 nucleotides upstream of the transcription start of the gene Ent2 (equilibrative nucleoside transporter 2). Ent2 P124 is the second mutant allele of this gene found in Drosophila. The genetic variability in Ent2 locus should be considered as a factor of risk for development of mental retardation and disorders of visual perception. Russian Journal of Genetics Springer Journals

Novel memory mutants in Drosophila: Behavioral characteristics of the P-Insertional mutant Ent2 P124

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SP MAIK Nauka/Interperiodica
Copyright © 2009 by MAIK Nauka
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
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