NH [Cu(phen)(PPh ) ]NO Br 2 3 2 3 NH NaN , H O, 60 °C, 2 h 3 2 antiepileptic drug Rufinamide (95%) Keywords Ruﬁnamide 2,6-Diﬂuoro benzyl bromide Green Media Antiepileptic drug 1,3-Dipolar cycloaddition Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2906-7) contains supplementary material, which is available to authorized users. & Kaushik Chanda firstname.lastname@example.org Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, India 123 4712 D. R. Meena et al. Introduction The disease, epilepsy caused by the chronic neurological disorder of the brain affecting almost people of all ages . According to the World Health Organization (WHO) estimates, out of the 50 million people suffering from different forms of epilepsy worldwide, 80% people is residing in developing countries [2, 3]. The majority of epileptic seizures are controlled by the use of anticonvulsants drugs [4, 5] which are often associated with related side-effects such as blurry vision, fatigue, sleepiness, and stomach upset . In view of the side effects, it is always imperative to develop the new anti epileptic drug (AED). An important example of 1,2,3-triazole ring containing antiepileptic drug is ruﬁnamide developed by Novartis and manufactured by Eisai
Research on Chemical Intermediates – Springer Journals
Published: Feb 25, 2017
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