Novel conserved synteny between human Chromosome 22 and cattle Chromosome 22 established by linkage mapping of transducin alpha-1 subunit (GNAZ)

Novel conserved synteny between human Chromosome 22 and cattle Chromosome 22 established by... 458 Mammalian Genome 8, Brief Data Reports Chr Xq28; HPTR, on Chr q26.1 [GDB]. These findings, together with ZOO-FISH analysis with human Chr X on porcine chromo- somes [7], indicate that almost all regions of human Chr X are conserved in porcine Chr X. However, the regional correspon- dence between porcine and human Chr X has not yet been clari- fied. Since the ARAF1 gene has been localized on human Chr Xpl 1.2, our findings, the assignment of ARAF1 on porcine Chr Xpll.2-pl3, give the first regional correspondence between the two species. The X Chr are highly conserved in Eutherian mam- mals [8], so that it is possible that porcine Chr Xp might corre- spond to human Chr Xp; and porcine Chr Xq, to human Chr Xq. However, the telomeric region of human X q-arm is reported to correspond to autosomal regions in prosimian species and mouse [9, 10]. Recently, Wilcox and associates [11] have revealed that the region of human Chr Xpter to pl 1.23, where ARAFI resides, corresponds to autosomal regions in marsupial and monotreme species. Therefore, additional genes, especially genes mapped in human Chr Xpter-pl 1.23 region, should be localized on the por- cine Chr X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Novel conserved synteny between human Chromosome 22 and cattle Chromosome 22 established by linkage mapping of transducin alpha-1 subunit (GNAZ)