Novel chlorhexidine dermal patches, preparation characterization and antimicrobial evaluation

Novel chlorhexidine dermal patches, preparation characterization and antimicrobial evaluation The purpose of this work is to develop chlorhexidine dermal patches using Eudragit® RL100 as the patch forming polymer. Solvent casting technique was employed in the preparation of the patches. The prepared patches, the corresponding physical mixtures, and the individual ingredients were physicochemically characterized by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) to investigate drug-excipient interactions. The results of the incompatibility studies indicated that the drug was molecularly distributed in Eudragit RL100 matrix. The developed patches were evaluated in terms of tensile strength, percentage of elongation, patch weight, surface pH, content uniformity, and drug dissolution profile. The developed chlorhexidine-medicated patches were flexible, transparent, homogenous, elegant, and smooth. Evaluation of the antimicrobial activity of the developed patches showed effective antimicrobial action against varieties of microorganisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Polymer Bulletin Springer Journals

Novel chlorhexidine dermal patches, preparation characterization and antimicrobial evaluation

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Organic Chemistry
ISSN
0170-0839
eISSN
1436-2449
D.O.I.
10.1007/s00289-017-1935-0
Publisher site
See Article on Publisher Site

Abstract

The purpose of this work is to develop chlorhexidine dermal patches using Eudragit® RL100 as the patch forming polymer. Solvent casting technique was employed in the preparation of the patches. The prepared patches, the corresponding physical mixtures, and the individual ingredients were physicochemically characterized by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) to investigate drug-excipient interactions. The results of the incompatibility studies indicated that the drug was molecularly distributed in Eudragit RL100 matrix. The developed patches were evaluated in terms of tensile strength, percentage of elongation, patch weight, surface pH, content uniformity, and drug dissolution profile. The developed chlorhexidine-medicated patches were flexible, transparent, homogenous, elegant, and smooth. Evaluation of the antimicrobial activity of the developed patches showed effective antimicrobial action against varieties of microorganisms.

Journal

Polymer BulletinSpringer Journals

Published: Feb 13, 2017

References

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