Novel and convenient one-pot strategy for regioselective synthesis of new 5-aryl-3-methyl-1-phenyl-1,2-dihydro-7aH-pyrazolo[3,4-c]pyridazin-7a-ol derivatives

Novel and convenient one-pot strategy for regioselective synthesis of new... & Mehdi Rimaz rimaz.mehdi@gmail.com Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran 123 3926 M. Rimaz et al. Keywords Pyrazolo[3,4-c]pyridazine  Arylglyoxalmonohydrate  DABCO  One- pot synthesis Introduction One-pot, multicomponent reactions (MCRs) constitute a unique and extraordinary synthetic strategy, offering benefits such as speed, synthetic efficiency, avoidance of purification steps, facile and convenient operation, and diversity [1–6]. 1,2-Dicarbonyl compounds, especially arylglyoxals (AGs), are very important precursors used to synthesize diverse organic compounds [7–11]. Synthesis of nitrogen-containing heterocyclic scaffolds has always represented an important and attractive area of chemical research, as these moieties have found extensive application in fields such as materials science [12, 13], catalysis [14–17], color chemistry [18–20], and most importantly drug chemistry [21–24]. Among nitrogen- containing heterocyclic compounds, pyrazole and its derivatives serve as building blocks for different pharmaceutically important heterocyclic systems and possess a wide range of biological activities [25, 26]; Some examples are shown in Fig. 1. Recently, fused-pyrazole heterocyclic scaffolds have been applied to obtain useful organic compounds that display unique biological activities [27–31]. In particular, pyrazolopyridazines show potential activities such as antifungal [32], anti-herpes simplex http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Novel and convenient one-pot strategy for regioselective synthesis of new 5-aryl-3-methyl-1-phenyl-1,2-dihydro-7aH-pyrazolo[3,4-c]pyridazin-7a-ol derivatives

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2848-5
Publisher site
See Article on Publisher Site

Abstract

& Mehdi Rimaz rimaz.mehdi@gmail.com Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran 123 3926 M. Rimaz et al. Keywords Pyrazolo[3,4-c]pyridazine  Arylglyoxalmonohydrate  DABCO  One- pot synthesis Introduction One-pot, multicomponent reactions (MCRs) constitute a unique and extraordinary synthetic strategy, offering benefits such as speed, synthetic efficiency, avoidance of purification steps, facile and convenient operation, and diversity [1–6]. 1,2-Dicarbonyl compounds, especially arylglyoxals (AGs), are very important precursors used to synthesize diverse organic compounds [7–11]. Synthesis of nitrogen-containing heterocyclic scaffolds has always represented an important and attractive area of chemical research, as these moieties have found extensive application in fields such as materials science [12, 13], catalysis [14–17], color chemistry [18–20], and most importantly drug chemistry [21–24]. Among nitrogen- containing heterocyclic compounds, pyrazole and its derivatives serve as building blocks for different pharmaceutically important heterocyclic systems and possess a wide range of biological activities [25, 26]; Some examples are shown in Fig. 1. Recently, fused-pyrazole heterocyclic scaffolds have been applied to obtain useful organic compounds that display unique biological activities [27–31]. In particular, pyrazolopyridazines show potential activities such as antifungal [32], anti-herpes simplex

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 6, 2017

References

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