& Mehdi Rimaz email@example.com Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran 123 3926 M. Rimaz et al. Keywords Pyrazolo[3,4-c]pyridazine Arylglyoxalmonohydrate DABCO One- pot synthesis Introduction One-pot, multicomponent reactions (MCRs) constitute a unique and extraordinary synthetic strategy, offering beneﬁts such as speed, synthetic efﬁciency, avoidance of puriﬁcation steps, facile and convenient operation, and diversity [1–6]. 1,2-Dicarbonyl compounds, especially arylglyoxals (AGs), are very important precursors used to synthesize diverse organic compounds [7–11]. Synthesis of nitrogen-containing heterocyclic scaffolds has always represented an important and attractive area of chemical research, as these moieties have found extensive application in ﬁelds such as materials science [12, 13], catalysis [14–17], color chemistry [18–20], and most importantly drug chemistry [21–24]. Among nitrogen- containing heterocyclic compounds, pyrazole and its derivatives serve as building blocks for different pharmaceutically important heterocyclic systems and possess a wide range of biological activities [25, 26]; Some examples are shown in Fig. 1. Recently, fused-pyrazole heterocyclic scaffolds have been applied to obtain useful organic compounds that display unique biological activities [27–31]. In particular, pyrazolopyridazines show potential activities such as antifungal , anti-herpes simplex
Research on Chemical Intermediates – Springer Journals
Published: Jan 6, 2017
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