& Mehdi Rimaz firstname.lastname@example.org Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran Department of Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran 123 3926 M. Rimaz et al. Keywords Pyrazolo[3,4-c]pyridazine Arylglyoxalmonohydrate DABCO One- pot synthesis Introduction One-pot, multicomponent reactions (MCRs) constitute a unique and extraordinary synthetic strategy, offering beneﬁts such as speed, synthetic efﬁciency, avoidance of puriﬁcation steps, facile and convenient operation, and diversity [1–6]. 1,2-Dicarbonyl compounds, especially arylglyoxals (AGs), are very important precursors used to synthesize diverse organic compounds [7–11]. Synthesis of nitrogen-containing heterocyclic scaffolds has always represented an important and attractive area of chemical research, as these moieties have found extensive application in ﬁelds such as materials science [12, 13], catalysis [14–17], color chemistry [18–20], and most importantly drug chemistry [21–24]. Among nitrogen- containing heterocyclic compounds, pyrazole and its derivatives serve as building blocks for different pharmaceutically important heterocyclic systems and possess a wide range of biological activities [25, 26]; Some examples are shown in Fig. 1. Recently, fused-pyrazole heterocyclic scaffolds have been applied to obtain useful organic compounds that display unique biological activities [27–31]. In particular, pyrazolopyridazines show potential activities such as antifungal , anti-herpes simplex
Research on Chemical Intermediates – Springer Journals
Published: Jan 6, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud