Curr Stem Cell Rep (2017) 3:202–209 DOI 10.1007/s40778-017-0090-8 CELL:CELL INTERACTIONS IN STEM CELL MAINTENANCE (D BONNET, SECTION EDITOR) 1 1,2 1 Fabio Pereira Lampreia & Joana Gonçalves Carmelo & Fernando Anjos-Afonso Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication Abstract research suggests that Notch signaling may play a role in Purpose of Review Understanding the signaling pathways homeostatic and regenerative hematopoiesis but further inves- that govern hematopoietic stem and progenitor cells tigation is necessary to understand how it is regulated by the (HSPCs) is fundamental to uncover their regulation and how different ligand/receptor pairings and the molecular mecha- this is skewed in hematological malignancies. Whether Notch nisms that are triggered. is necessary for the regulation of mammalian HSPCs is still . . . unclear. We therefore critically review the current literature on Keywords Notch signaling HSC Niche MPD the role of Notch in HSPCs. Recent Findings HSPCs have shown different requirements for Notch signals in vitro and in vivo and at different stages of Introduction: Brief Description of Notch Signaling differentiation. Additionally, bone marrow niche cells activate Notch signaling in HSPCs enhancing their regenerative and Detailed reviews on the Notch pathway can
Current Stem Cell Reports – Springer Journals
Published: Jul 10, 2017
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