Notch Signaling in the Regulation of Hematopoietic Stem Cell

Notch Signaling in the Regulation of Hematopoietic Stem Cell Curr Stem Cell Rep (2017) 3:202–209 DOI 10.1007/s40778-017-0090-8 CELL:CELL INTERACTIONS IN STEM CELL MAINTENANCE (D BONNET, SECTION EDITOR) 1 1,2 1 Fabio Pereira Lampreia & Joana Gonçalves Carmelo & Fernando Anjos-Afonso Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication Abstract research suggests that Notch signaling may play a role in Purpose of Review Understanding the signaling pathways homeostatic and regenerative hematopoiesis but further inves- that govern hematopoietic stem and progenitor cells tigation is necessary to understand how it is regulated by the (HSPCs) is fundamental to uncover their regulation and how different ligand/receptor pairings and the molecular mecha- this is skewed in hematological malignancies. Whether Notch nisms that are triggered. is necessary for the regulation of mammalian HSPCs is still . . . unclear. We therefore critically review the current literature on Keywords Notch signaling HSC Niche MPD the role of Notch in HSPCs. Recent Findings HSPCs have shown different requirements for Notch signals in vitro and in vivo and at different stages of Introduction: Brief Description of Notch Signaling differentiation. Additionally, bone marrow niche cells activate Notch signaling in HSPCs enhancing their regenerative and Detailed reviews on the Notch pathway can Current Stem Cell Reports Springer Journals

Notch Signaling in the Regulation of Hematopoietic Stem Cell

Loading next page...
Springer International Publishing
Copyright © 2017 by The Author(s)
Life Sciences; Cell Biology; Stem Cells
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial