Diabetes mellitus is a heterogeneous group of conditions defined by resultant chronic hyperglycemia. Given the increasing prevalence of diabetes mellitus and the increasing understanding of genetic etiologies, we present a broad review of rare genetic forms of diabetes that have differing diagnostic and/or treatment implications from type 1 and type 2 diabetes. Advances in understanding the genotype-phenotype associations in these rare forms of diabetes offer clinically available examples of evolving precision medicine where defining the correct genetic etiology can radically alter treatment approaches. In this review, we focus on forms of monogenic diabetes, mitochondrial diabetes, and syndromic diabetes. . . . . Keywords Monogenic diabetes Mitochondrial diabetes Syndromic diabetes Maturity onset diabetes of the young (MODY) Diabetes mellitus 1 Introduction 1) Type 1 diabetes 2) Type 2 diabetes The tsunami of diabetes mellitus has not shown any signs of 3) Gestational diabetes mellitus first diagnosed in 2nd or 3rd slowing down as prevalence continues to climb, with 425 trimester million affected in the world according to the International 4) Diabetes mellitus due to other causes, in which genetic Diabetes Federation  that is expected to increase to 629 diabetes syndromes are listed. million in 2045. However, the term Bdiabetes
Reviews in Endocrine and Metabolic Disorders – Springer Journals
Published: May 18, 2018
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