Drugs - Real World Outcomes (2017) 4:127–137 DOI 10.1007/s40801-017-0113-x ORIGINAL RESEARCH ARTICLE Non-Steroidal Anti-Inﬂammatory Drug Use and the Risk of Acute Myocardial Infarction in the General German Population: A Nested Case–Control Study 1,2 1 1 • • Kathrin Tho¨ne Bianca Kollhorst Tania Schink Published online: 4 July 2017 The Author(s) 2017. This article is an open access publication Abstract sampling. Multivariable conditional logistic regression was Introduction Use of non-steroidal anti-inﬂammatory drugs applied to estimate odds ratios (ORs) and 95% conﬁdence (NSAIDs) has been associated with an increased relative intervals (CIs). Duration of NSAID use was calculated by risk of acute myocardial infarction (AMI), but the label the cumulative amount of dispensed deﬁned daily doses warnings refer particularly to patients with cardiovascular (DDDs), and stratiﬁed analyses were conducted for risk factors. The magnitude of relative AMI risk for potential effect modiﬁers. patients with and without cardiovascular risk factors varies Results Overall, 17,236 AMI cases were matched to between studies depending on the drugs and doses studied. 1,714,006 controls. Elevated relative AMI risks were seen Objectives The aim of our study was to estimate popula- for current users of ﬁxed combinations of diclofenac with tion-based relative AMI risks for individual and
Drugs - Real World Outcomes – Springer Journals
Published: Jul 4, 2017
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