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B. Takens-Kwak, H. Jongsma (1992)
Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatmentsPflügers Archiv, 422
P.R. Brink, V. Valiunas, S.V. Ramanan (1999)
High open probability demonstrated through non-stationary noise analysis in three gap junctions
V. Valiunas, R. Weingart, P. Brink (2000)
Formation of heterotypic gap junction channels by connexins 40 and 43.Circulation research, 86 2
Ding He, Jean Jiang, S. Taffet, Janis Burt (1999)
Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America, 96 11
V. Valiunas, R. Weingart (2001)
Co-operativity between mouse connexin30 gap junction channelsPflügers Archiv, 441
R. Veenstra, Hong-Zahn Wang, Eric Beyer, S. Ramanan, Peter Brink (1994)
Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities.Biophysical journal, 66 6
F. Noceti, Pietro Baldelli, Xiangyang Wei, Ning Qin, L. Toro, L. Birnbaumer, E. Stefani (1996)
Effective gating charges per channel in voltage-dependent K+ and Ca2+ channelsThe Journal of General Physiology, 108
E. Trexler, M. Bennett, T. Bargiello, V. Verselis (1996)
Voltage gating and permeation in a gap junction hemichannel.Proceedings of the National Academy of Sciences of the United States of America, 93 12
W. Dun, M. Jiang, G. Tseng (1999)
Allosteric effects of mutations in the extracellular S5-P loop on the gating and ion permeation properties of the hERG potassium channelPflügers Archiv, 439
A. Harris (2001)
Emerging issues of connexin channels: biophysics fills the gapQuarterly Reviews of Biophysics, 34
F. Sigworth (1985)
Open channel noise. I. Noise in acetylcholine receptor currents suggests conformational fluctuations.Biophysical journal, 47 5
S. Ramanan, Peter Brink, K. Varadaraj, E. Peterson, K. Schirrmacher, K. Banach (1999)
A three-state model for connexin37 gating kinetics.Biophysical journal, 76 5
Ye Chen-Izu, Alonso Moreno, Robert Spangler (2001)
Opposing gates model for voltage gating of gap junction channels.American journal of physiology. Cell physiology, 281 5
R. Keynes (1975)
The ionic channels in excitable membranes.Ciba Foundation symposium, 31
F.J. Sigworth (1980)
The variance of sodium currents at the node of RanvierJ. Physiol, 307
P. Brink, S. Ramanan, G. Christ (1996)
Human connexin 43 gap junction channel gating: evidence for mode shifts and/or heterogeneity.The American journal of physiology, 271 1 Pt 1
Norman Lavy (1994)
Letters: Omeprazole and Vitamin B12Annals of Internal Medicine, 121
R. Veenstra (2001)
Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements.Biophysical journal, 80 5
F. Bukauskas, Angele Bukauskiene, V. Verselis, M. Bennett (2002)
Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: Properties of fast and slow gating mechanismsProceedings of the National Academy of Sciences of the United States of America, 99
T. White, R. Bruzzone (1996)
Multiple connexin proteins in single intercellular channels: Connexin compatibility and functional consequencesJournal of Bioenergetics and Biomembranes, 28
F. Bukauskas, C. Elfgang, Klaus, Willecke, R. Weingart (1995)
Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells.Biophysical journal, 68 6
L. Rela, L. Szczupak (2004)
Gap junctionsMolecular Neurobiology, 30
J. Neyton, A. Trautmann (1985)
Single-channel currents of an intercellular junctionNature, 317
T. Lu, A. Ting, J. Mainland, L. Jan, P. Schultz, Jian Yang (2001)
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filterNature Neuroscience, 4
V. Valiunas, F. Bukauskas, R. Weingart (1997)
Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells.Circulation research, 80 5
A. Moreno, M. Rook, Glenn Fishman, D. Spray (1994)
Gap junction channels: distinct voltage-sensitive and -insensitive conductance states.Biophysical journal, 67 1
F. Ashcroft (2000)
Gap junction channels
R. Wilders, H. Jongsma (1992)
Limitations of the dual voltage clamp method in assaying conductance and kinetics of gap junction channels.Biophysical journal, 63 4
K. Willecke, Jürgen Eiberger, Joachim Degen, D. Eckardt, A. Romualdi, M. Güldenagel, U. Deutsch, G. Söhl (2002)
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome, 383
V. Valiunas, E. Beyer, P. Brink (2002)
Cardiac Gap Junction Channels Show Quantitative Differences in SelectivityCirculation Research: Journal of The American Heart Association, 91
F. Sigworth (1980)
The variance of sodium current fluctuations at the node of RanvierThe Journal of Physiology, 307
(1993)
Intl
J. Burt, D. Spray (1988)
Inotropic agents modulate gap junctional conductance between cardiac myocytes.The American journal of physiology, 254 6 Pt 2
H. Musa, R. Veenstra (2003)
Voltage-dependent blockade of connexin40 gap junctions by spermine.Biophysical journal, 84 1
Non-stationary fluctuation analysis was applied to macroscopic records of junctional currents arising from homotypic Cx37 and Cx43 gap junction channels expressed in RIN cells. The data were analyzed by a modification of existing analytical methods that takes endemic uncoupling into account. The results are consistent with both channels having open probabilities ranging from 0.7 to near unity for low transjunctional voltages. The analysis also yielded estimates of single-channel conductances for the two channel types similar to those seen in single-channel recordings. The results presented here show that fluctuation analysis can be used to extract single-channel gap junctional conductances from macroscopic double whole-cell recordings. These results also constitute empirically determined estimates of the open probability that are not model-dependent.
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2005
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