Non-operative meningiomas: long-term follow-up of 136 patients

Non-operative meningiomas: long-term follow-up of 136 patients Background Improving access to neuroradiology investigations has led to an increased rate of diagnosis of incidental meningiomas. Method A cohort of 136 incidental meningioma patients collected by a single neurosurgeon in a single neurosurgical centre is retrospectively analysed between 2002 and 2016. Demographic data, imaging and clinical features are presented. The radiolog- ical factors associated with meningiomas progression are also presented. Results The mean age at diagnosis was 65 (range, 33–94) years. Univariate analysis showed oedema was most strongly correlated with progression (p = 0.010) followed by hyperintensity in T2-weighted (T2W) MRI (p = 0.029) and in Flair-T2W MRI (p =0.017). Isointensity in Flair-T2W MRI (0.004) was most strongly correlated with non-progression of the meningioma followed by calci- fication (p = 0.007), older age (p = 0.087), hypointensity in Flair-T2W MRI (p = 0.014) sequences and in T2W MRI (p = 0.096). In multivariate analysis, the strongest radiological factor predictive of progression was peritumoural oedema (p = 0.016) and that of non-progression was calcification (p = 0.002). At the end of the median follow-up (FU) of 43 (range, 4–150) months, 109 (80%) patients remained clinically stable, 13 (10%) became symptomatic and 14 (10%) showed clinical and radiological progression. Conclusions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Neurochirurgica Springer Journals

Non-operative meningiomas: long-term follow-up of 136 patients

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Medicine & Public Health; Neurosurgery; Interventional Radiology; Neuroradiology; Neurology; Surgical Orthopedics; Minimally Invasive Surgery
ISSN
0001-6268
eISSN
0942-0940
D.O.I.
10.1007/s00701-018-3554-4
Publisher site
See Article on Publisher Site

Abstract

Background Improving access to neuroradiology investigations has led to an increased rate of diagnosis of incidental meningiomas. Method A cohort of 136 incidental meningioma patients collected by a single neurosurgeon in a single neurosurgical centre is retrospectively analysed between 2002 and 2016. Demographic data, imaging and clinical features are presented. The radiolog- ical factors associated with meningiomas progression are also presented. Results The mean age at diagnosis was 65 (range, 33–94) years. Univariate analysis showed oedema was most strongly correlated with progression (p = 0.010) followed by hyperintensity in T2-weighted (T2W) MRI (p = 0.029) and in Flair-T2W MRI (p =0.017). Isointensity in Flair-T2W MRI (0.004) was most strongly correlated with non-progression of the meningioma followed by calci- fication (p = 0.007), older age (p = 0.087), hypointensity in Flair-T2W MRI (p = 0.014) sequences and in T2W MRI (p = 0.096). In multivariate analysis, the strongest radiological factor predictive of progression was peritumoural oedema (p = 0.016) and that of non-progression was calcification (p = 0.002). At the end of the median follow-up (FU) of 43 (range, 4–150) months, 109 (80%) patients remained clinically stable, 13 (10%) became symptomatic and 14 (10%) showed clinical and radiological progression. Conclusions

Journal

Acta NeurochirurgicaSpringer Journals

Published: Jun 6, 2018

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