International Journal of Hematology (2018) 107:390–391 https://doi.org/10.1007/s12185-017-2377-z IMAGES IN HEMATOLOGY Non‑alcoholic steatohepatitis induced by induction chemotherapy for pediatric acute lymphoblastic leukemia 1 1 1 1 1 2 Masaki Yamamoto · Tsukasa Hori · Keita Igarashi · Kotoe Iesato · Makoto Saito · Koji Miyanishi · 3 3 1 Noriaki Kikuchi · Hiromi Fujita · Hiroyuki Tsutsumi Received: 21 September 2017 / Revised: 22 November 2017 / Accepted: 24 November 2017 / Published online: 27 November 2017 © The Japanese Society of Hematology 2017 An 8-year-old boy presented with acute lymphoblastic leu- Computed tomography scan on day 36 after the start of treat- kemia (ALL). He had been obese from early childhood, ment showed severe fatty liver and hepatosplenomegaly, and and the degree of obesity was 56.8% at onset of ALL. On the thickness of the bile tract wall suggested complication admission, his initial complete blood cell count showed a by cholangitis (Fig. 1b). white blood cell count of 14.4 × 10 /L with 61% lymph- Maximum γ-GTP was 1066 IU/L on day 36, and the max- oblasts, hemoglobin of 8.6 g/dL, and a platelet count of imum total bilirubin level was 8.2 mg/dL on day 42. He was 37 × 10 /L. Biochemical tests showed a marked elevation treated with supportive care. The induction chemotherapy of transaminase (AST 428 IU/L,
International Journal of Hematology – Springer Journals
Published: Nov 27, 2017
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