No evidence of persistent parvovirus B19 viremia among Iranian patients with HIV after a 1-year follow-up

No evidence of persistent parvovirus B19 viremia among Iranian patients with HIV after a 1-year... Recent studies have demonstrated that, in common with other latent viruses, parvovirus B19 infection can be controlled by the host immune response but may persist in some places such as the bone marrow. Persistent B19 infection has been found in both immunocompetent and immunocompromised individuals, such as patients infected with human immunodeficiency virus (HIV). However, there is limited data regarding long-term B19 viremia in HIV patients. In this study, we investigated virological and hematological findings, and also the clinical outcome, of seven cases of HIV/B19 coinfection (confirmed by PCR) after one year. These cases were provided from a previous study on patients with HIV infection that found B19 DNA in 13 cases. Seven of these 13 patients were available after 1 year, and we retested them for B19 viremia and B19-specific antibodies. B19 IgG was tested by ELISA, and B19 DNA was assessed by nested PCR. Anemia was not observed in these cases. All subjects had cleared viremia, but B19 IgG seroconversion occurred in two cases. No significant changes in CD4 and hemoglobin occurred. The results of this study indicate that B19 infection in HIV patients is a subtle infection and that B19 viremia is not a long-term event. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

No evidence of persistent parvovirus B19 viremia among Iranian patients with HIV after a 1-year follow-up

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Publisher
Springer Vienna
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-016-2782-2
Publisher site
See Article on Publisher Site

Abstract

Recent studies have demonstrated that, in common with other latent viruses, parvovirus B19 infection can be controlled by the host immune response but may persist in some places such as the bone marrow. Persistent B19 infection has been found in both immunocompetent and immunocompromised individuals, such as patients infected with human immunodeficiency virus (HIV). However, there is limited data regarding long-term B19 viremia in HIV patients. In this study, we investigated virological and hematological findings, and also the clinical outcome, of seven cases of HIV/B19 coinfection (confirmed by PCR) after one year. These cases were provided from a previous study on patients with HIV infection that found B19 DNA in 13 cases. Seven of these 13 patients were available after 1 year, and we retested them for B19 viremia and B19-specific antibodies. B19 IgG was tested by ELISA, and B19 DNA was assessed by nested PCR. Anemia was not observed in these cases. All subjects had cleared viremia, but B19 IgG seroconversion occurred in two cases. No significant changes in CD4 and hemoglobin occurred. The results of this study indicate that B19 infection in HIV patients is a subtle infection and that B19 viremia is not a long-term event.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2016

References

  • Seroprevalence of parvovirus B19 in fibromyalgia syndrome
    Buyukkose, M; Kozanoglu, E; Basaran, S; Bayramoglu, O; Yarkin, F
  • Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum
    Erdman, DD; Usher, MJ; Tsou, C; Caul, EO; Gary, GW; Kajigaya, S; Young, NS; Anderson, LJ
  • Human parvovirus B19 infections: routine diagnosis by a new nested polymerase chain reaction assay
    Cassinotti, P; Weitz, M; Siegl, G
  • Parvovirus B19 infection and autoimmune disease
    Lehmann, HW; Landenberg, P; Modrow, S
  • Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV
    Azadmanesh, K; Mohraz, M; Kazemimanesh, M; Aghakhani, A; Foroughi, M; Banifazl, M; Eslamifar, A; Ramezani, A
  • Persistent parvovirus B19 infection in non-erythroid tissues: possible role in the inflammatory and disease process
    Adamson-Small, LA; Ignatovich, IV; Laemmerhirt, MG; Hobbs, JA

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