Nivolumab

Nivolumab Reactions 1680, p259 - 2 Dec 2017 Ulcerative colitis: case report An 85-year-old woman developed ulcerative colitis during treatment with nivolumab [dosage and route not stated]. The woman, who had an 18 month history of lung adenocarcinoma, did not improved with chemotherapy including vinorelbine or docetaxel. Hence, she was started on nivolumab as a third-line therapy. She developed diarrhoea and haematochezia, three months after starting nivolumab. Fecal culture, serological tests and Clostridium difficile toxin assay did not reveal any significant findings. Subsequently, a colonoscopy showed loss of visible vascular pattern, purulent fluid throughout the colon and oedema. The endoscopic findings were indicative of ulcerative colitis. Eosin and haematoxylin staining of a biopsy specimen of colonic mucosa revealed goblet cell depletion, diffuse inflammatory cell infiltration and crypt abscess. Nivolumab-induced colitis was suspected based on the clinical course and the findings. The woman was started on methylprednisolone, and clinical symptoms resolved within a few days. A repeat endoscopy showed marked improvement after 3 weeks of therapy with methylprednisolone. Subsequently, methylprednisolone dose was gradually tapered with no recurrence of symptoms. Author comment: "Based on the clinical course and these findings, nivolumab-induced colitis was suspected." Abe K, et al. Inflammatory Bowel Disease in an Elderly Woman after Nivolumab Administration. American Journal of Gastroenterology 112: 1636, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1038/ajg.2017.372 - Japan 803284792 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Nivolumab

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39190-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p259 - 2 Dec 2017 Ulcerative colitis: case report An 85-year-old woman developed ulcerative colitis during treatment with nivolumab [dosage and route not stated]. The woman, who had an 18 month history of lung adenocarcinoma, did not improved with chemotherapy including vinorelbine or docetaxel. Hence, she was started on nivolumab as a third-line therapy. She developed diarrhoea and haematochezia, three months after starting nivolumab. Fecal culture, serological tests and Clostridium difficile toxin assay did not reveal any significant findings. Subsequently, a colonoscopy showed loss of visible vascular pattern, purulent fluid throughout the colon and oedema. The endoscopic findings were indicative of ulcerative colitis. Eosin and haematoxylin staining of a biopsy specimen of colonic mucosa revealed goblet cell depletion, diffuse inflammatory cell infiltration and crypt abscess. Nivolumab-induced colitis was suspected based on the clinical course and the findings. The woman was started on methylprednisolone, and clinical symptoms resolved within a few days. A repeat endoscopy showed marked improvement after 3 weeks of therapy with methylprednisolone. Subsequently, methylprednisolone dose was gradually tapered with no recurrence of symptoms. Author comment: "Based on the clinical course and these findings, nivolumab-induced colitis was suspected." Abe K, et al. Inflammatory Bowel Disease in an Elderly Woman after Nivolumab Administration. American Journal of Gastroenterology 112: 1636, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1038/ajg.2017.372 - Japan 803284792 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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