Reactions 1680, p259 - 2 Dec 2017 Ulcerative colitis: case report An 85-year-old woman developed ulcerative colitis during treatment with nivolumab [dosage and route not stated]. The woman, who had an 18 month history of lung adenocarcinoma, did not improved with chemotherapy including vinorelbine or docetaxel. Hence, she was started on nivolumab as a third-line therapy. She developed diarrhoea and haematochezia, three months after starting nivolumab. Fecal culture, serological tests and Clostridium difficile toxin assay did not reveal any significant findings. Subsequently, a colonoscopy showed loss of visible vascular pattern, purulent fluid throughout the colon and oedema. The endoscopic findings were indicative of ulcerative colitis. Eosin and haematoxylin staining of a biopsy specimen of colonic mucosa revealed goblet cell depletion, diffuse inflammatory cell infiltration and crypt abscess. Nivolumab-induced colitis was suspected based on the clinical course and the findings. The woman was started on methylprednisolone, and clinical symptoms resolved within a few days. A repeat endoscopy showed marked improvement after 3 weeks of therapy with methylprednisolone. Subsequently, methylprednisolone dose was gradually tapered with no recurrence of symptoms. Author comment: "Based on the clinical course and these findings, nivolumab-induced colitis was suspected." Abe K, et al. Inflammatory Bowel Disease in an Elderly Woman after Nivolumab Administration. American Journal of Gastroenterology 112: 1636, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1038/ajg.2017.372 - Japan 803284792 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud