Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer_journal/nine-3-ketoacyl-coa-thiolases-kats-and-acetoacetyl-coa-thiolases-acats-CQU74ee4Bx
References (58)
-
K. Pohlmeyer, Jürgen Soll, T. Steinkamp, S. Hinnah, Richard Wagner (1997)
Isolation and characterization of an amino acid-selective channel protein present in the chloroplastic outer envelope membrane.Proceedings of the National Academy of Sciences of the United States of America, 94 17
-
Y. Fujiki, Tokuyuki Sato, Masaki Ito, A. Watanabe (2000)
Isolation and Characterization of cDNA Clones for the E1β and E2 Subunits of the Branched-chain α-Ketoacid Dehydrogenase Complex in Arabidopsis *The Journal of Biological Chemistry, 275
-
Itsara Pracharoenwattana, Johanna Cornah, Steven M. L. Smith (2005)
Arabidopsis Peroxisomal Citrate Synthase Is Required for Fatty Acid Respiration and Seed Germinationw⃞The Plant Cell Online, 17
-
P. Lange, P. Eastmond, K. Madagan, I. Graham (2004)
An Arabidopsis mutant disrupted in valine catabolism is also compromised in peroxisomal fatty acid β‐oxidationFEBS Letters, 571
-
Ali Pendle, G. Clark, R. Boon, Dominika Lewandowska, Y. Lam, J. Andersen, M. Mann, A. Lamond, John Brown, P. Shaw (2004)
Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions.Molecular biology of the cell, 16 1
-
T. Tsukamoto, S. Hata, S. Yokota, S. Miura, Y. Fujiki, M. Hijikata, S. Miyazawa, T. Hashimoto, T. Osumi (1994)
Characterization of the signal peptide at the amino terminus of the rat peroxisomal 3-ketoacyl-CoA thiolase precursor.The Journal of biological chemistry, 269 8
-
A. Baker, I. Sparkes (2005)
Peroxisome protein import: some answers, more questions.Current opinion in plant biology, 8 6
-
J. Heazlewood, Julian Tonti-Filippini, R. Verboom (2005)
Combining Experimental and Predicted Datasets for Determination of the Subcellular Location of Proteins in Arabidopsis1[w]Plant Physiology, 139
-
V. Kruft, Holger Eubel, L. Jänsch, Wolf Werhahn, H. Braun (2001)
Proteomic approach to identify novel mitochondrial proteins in Arabidopsis.Plant physiology, 127 4
-
M. Tanudji, P. Dessi, M. Murcha, J. Whelan (2001)
Protein import into plant mitochondria: precursor proteins differ in ATP and membrane potential requirementsPlant Molecular Biology, 45
-
May-Nee Lee, J. Whelan (2004)
Identification of Signals Required for Import of the Soybean FAd Subunit of ATP Synthase into MitochondriaPlant Molecular Biology, 54
-
Kiana Toufighi, S. Brady, Ryan Austin, E. Ly, N. Provart (2005)
The Botany Array Resource: e-Northerns, Expression Angling, and promoter analyses.The Plant journal : for cell and molecular biology, 43 1
-
A. Saeed, V. Sharov, J. White, J. Li, W. Liang, N. Bhagabati, J. Braisted, M. Kłapa, T. Currier, M. Thiagarajan, A. Sturn, M. Snuffin, A. Rezantsev, D. Popov, A. Ryltsov, E. Kostukovich, I. Borisovsky, Z. Liu, A. Vinsavich, V. Trush, John Quackenbush (2003)
TM4: a free, open-source system for microarray data management and analysis.BioTechniques, 34 2
-
G. Tian, A. Mohanty, S. Chary, Shijun Li, B. Paap, G. Drakakaki, Charles Kopec, Jianxiong Li, D. Ehrhardt, D. Jackson, S. Rhee, N. Raikhel, V. Citovsky (2004)
High-Throughput Fluorescent Tagging of Full-Length Arabidopsis Gene Products in Planta1Plant Physiology, 135
-
V. Germain, E. Rylott, T. Larson, S. Sherson, N. Bechtold, J. Carde, J. Bryce, I. Graham, Steven Smith (2001)
Requirement for 3-ketoacyl-CoA thiolase-2 in peroxisome development, fatty acid beta-oxidation and breakdown of triacylglycerol in lipid bodies of Arabidopsis seedlings.The Plant journal : for cell and molecular biology, 28 1
-
N. Picault, M. Hodges, L. Palmieri, F. Palmieri (2004)
The growing family of mitochondrial carriers in Arabidopsis.Trends in plant science, 9 3
-
Manish Kumar, R. Verma, Gajendra Raghava (2006)
Prediction of Mitochondrial Proteins Using Support Vector Machine and Hidden Markov Model*Journal of Biological Chemistry, 281
-
O. Emanuelsson, Henrik Nielsen, S. Brunak, G. Heijne (2000)
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.Journal of molecular biology, 300 4
-
M. Murcha, A. Millar, J. Whelan (2005)
The N-terminal cleavable extension of plant carrier proteins is responsible for efficient insertion into the inner mitochondrial membrane.Journal of molecular biology, 351 1
-
T. Fukao, C. Scriver, N. Kondo (2001)
The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (beta-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients.Molecular genetics and metabolism, 72 2
-
R. Lister, O. Chew, May-Nee Lee, J. Heazlewood, R. Clifton, Karen Parker, A. Millar, J. Whelan (2004)
A Transcriptomic and Proteomic Characterization of the Arabidopsis Mitochondrial Protein Import Apparatus and Its Response to Mitochondrial Dysfunction1[w]Plant Physiology, 134
-
B. Winning, C. Sarah, P. Purdue, C. Day, C. Leaver (1992)
The adenine nucleotide translocator of higher plants is synthesized as a large precursor that is processed upon import into mitochondria.The Plant journal : for cell and molecular biology, 2 5
-
J. Rassow, P. Dekker, S. Wilpe, M. Meijer, J. Soll (1999)
The preprotein translocase of the mitochondrial inner membrane: function and evolution.Journal of molecular biology, 286 1
-
N. Taylor, J. Heazlewood, D. Day, A. Millar (2004)
Lipoic Acid-Dependent Oxidative Catabolism of α-Keto Acids in Mitochondria Provides Evidence for Branched-Chain Amino Acid Catabolism in Arabidopsis1Plant Physiology, 134
-
T. Kleffmann, Doris Russenberger, A. Zychlinski, W. Christopher, Kimmen Sjölander, W. Gruissem, S. Baginsky (2004)
The Arabidopsis thaliana Chloroplast Proteome Reveals Pathway Abundance and Novel Protein FunctionsCurrent Biology, 14
-
J. Peretó, P. López‐García, D. Moreira (2005)
Phylogenetic Analysis of Eukaryotic Thiolases Suggests Multiple Proteobacterial OriginsJournal of Molecular Evolution, 61
-
O. Chew, J. Whelan (2004)
Just read the message: a model for sorting of proteins between mitochondria and chloroplasts.Trends in plant science, 9 7
-
J. Thompson, T. Gibson, F. Plewniak, F. Jeanmougin, D. Higgins (1997)
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.Nucleic acids research, 25 24
-
M. Hooks (2002)
Molecular Biology, Enzymology, and Physiology of β-Oxidation -
Tanya Johnson, L. Olsen (2003)
Import of the Peroxisomal Targeting Signal Type 2 Protein 3-Ketoacyl-Coenzyme A Thiolase into Glyoxysomes1Plant Physiology, 133
-
T. RoermundvanC.W., H. Waterham, L. Ijlst, R. Wanders (2003)
Fatty acid metabolism in Saccharomyces cerevisiaeCellular and Molecular Life Sciences CMLS, 60
-
M. Eisen, P. Spellman, P. Brown, D. Botstein (1998)
Cluster analysis and display of genome-wide expression patterns.Proceedings of the National Academy of Sciences of the United States of America, 95 25
-
JL Heazlewood, JS Tonti-Filippini, AM Gout, DA Day, J Whelan, AH Millar (2004)
Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteinsPlant Cell, 16
-
I. Graham, P. Eastmond (2002)
Pathways of straight and branched chain fatty acid catabolism in higher plants.Progress in lipid research, 41 2
-
H. Bannai, Y. Tamada, O. Maruyama, K. Nakai, S. Miyano (2002)
Extensive feature detection of N-terminal protein sorting signalsBioinformatics, 18 2
-
David Thirkettle-Watts, T. McCabe, R. Clifton, C. Moore, P. Finnegan, D. Day, J. Whelan (2003)
Analysis of the Alternative Oxidase Promoters from Soybean1Plant Physiology, 133
-
O. Chew, Charlotta Rudhe, E. Glaser, J. Whelan (2003)
Characterization of the targeting signal of dual-targeted pea glutathione reductasePlant Molecular Biology, 53
-
Simon Derrick, P. Large (1993)
Activities of the enzymes of the Ehrlich pathway and formation of branched-chain alcohols in Saccharomyces cerevisiae and Candida utilis grown in continuous culture on valine or ammonium as sole nitrogen source.Journal of general microbiology, 139 11
-
M. Murcha, Dina Elhafez, A. Millar, J. Whelan (2004)
The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase.Journal of molecular biology, 344 2
-
J. Thompson, D. Higgins, T. Gibson (1994)
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.Nucleic acids research, 22 22
-
C. Masterson, C. Wood (2001)
Mitochondrial and peroxisomal β-oxidation capacities of organs from a non–oilseed plantProceedings of the Royal Society of London. Series B: Biological Sciences, 268
-
C. Danpure, M. Lumb, G. Birdsey, Xiaoxuan Zhang (2003)
Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease.Biochimica et biophysica acta, 1647 1-2
-
Kayoko Yamada, Jun-Man Lim, Joseph Dale, Huaming Chen, P. Shinn, C. Palm, Audrey Southwick, Hank Wu, Christopher Kim, M. Nguyen, Paul Pham, Rosa Cheuk, George Karlin-Newmann, Shirley Liu, Bao Lam, H. Sakano, Troy Wu, Guixia Yu, Molly Miranda, H. Quach, M. Tripp, Charlie Chang, J. Lee, Mitsue Toriumi, Marie Chan, C. Tang, C. Onodera, Justine Deng, Kenji Akiyama, Yasser Ansari, T. Arakawa, Jenny Banh, Fumika Banno, Leah Bowser, Shelise Brooks, Piero Carninci, Qimin Chao, Nathan Choy, A. Enju, A. Goldsmith, M. Gurjal, Nancy Hansen, Y. Hayashizaki, Chanda Johnson-Hopson, Vickie Hsuan, K. Iida, Meagan Karnes, Shehnaz Khan, Eric Koesema, Junko Ishida, P. Jiang, Ted Jones, J. Kawai, Asako Kamiya, Cristina Meyers, Maiko Nakajima, M. Narusaka, M. Seki, Tetsuya Sakurai, Masakazu Satou, R. Tamse, M. Vaysberg, Erika Wallender, Cecilia Wong, Y. Yamamura, Shiaulou Yuan, K. Shinozaki, Ronald Davis, A. Theologis, J. Ecker (2003)
Empirical Analysis of Transcriptional Activity in the Arabidopsis GenomeScience, 302
-
S. Hua, Zhirong Sun (2001)
Support vector machine approach for protein subcellular localization predictionBioinformatics, 17 8
-
J. Whelan, M. Hugosson, E. Glaser, D. Day (1995)
Studies on the import and processing of the alternative oxidase precursor by isolated soybean mitochondriaPlant Molecular Biology, 27
-
Brian Bathgate, A. Baker, C. Leaver (1989)
Two genes encode the adenine nucleotide translocator of maize mitochondria. Isolation, characterisation and expression of the structural genes.European journal of biochemistry, 183 2
-
M. Claros, M. Claros, P. Vincens (1996)
Computational method to predict mitochondrially imported proteins and their targeting sequences.European journal of biochemistry, 241 3
-
J. Campanella, Ledion Bitincka, John Smalley (2003)
MatGAT: An application that generates similarity/identity matrices using protein or DNA sequencesBMC Bioinformatics, 4
-
T. Mockler, S. Chan, Ambika Sundaresan, Huaming Chen, S. Jacobsen, J. Ecker (2005)
Applications of DNA tiling arrays for whole-genome analysis.Genomics, 85 1
-
J. Heazlewood, Julian Tonti-Filippini, Alexander Gout, David Day, J. Whelan, A. Millar (2004)
Experimental Analysis of the Arabidopsis Mitochondrial Proteome Highlights Signaling and Regulatory Components, Provides Assessment of Targeting Prediction Programs, and Indicates Plant-Specific Mitochondrial Proteins Online version contains Web-only data. Article, publication date, and citation infThe Plant Cell Online, 16
-
O. Emanuelsson, A. Elofsson, G. Heijne, S. Cristobal (2003)
In silico prediction of the peroxisomal proteome in fungi, plants and animals.Journal of molecular biology, 330 2
-
Philip Zimmermann, Matthias Hirsch-Hoffmann, L. Hennig, W. Gruissem (2004)
GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox1[w]Plant Physiology, 136
-
I. Small, N. Peeters, F. Legeai, C. Lurin (2004)
Predotar: A tool for rapidly screening proteomes for N‐terminal targeting sequencesPROTEOMICS, 4
-
MA Hooks (2002)
Plant peroxisomes -
S. Koh, A. André, Herb Edwards, D. Ehrhardt, S. Somerville (2005)
Arabidopsis thaliana subcellular responses to compatible Erysiphe cichoracearum infections.The Plant journal : for cell and molecular biology, 44 3
-
S. Footitt, S. Slocombe, Victoria Larner, S. Kurup, Yaosheng Wu, T. Larson, I. Graham, A. Baker, M. Holdsworth (2002)
Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDPThe EMBO Journal, 21
-
S. Brugière, S. Kowalski, M. Ferro, D. Seigneurin-Berny, S. Miras, D. Salvi, S. Ravanel, P. d'Hérin, J. Garin, J. Bourguignon, J. Joyard, N. Rolland (2004)
The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions.Phytochemistry, 65 12
-
S. Cutler, D. Ehrhardt, Joel Griffitts, C. Somerville (2000)
Random GFP::cDNA fusions enable visualization of subcellular structures in cells of Arabidopsis at a high frequency.Proceedings of the National Academy of Sciences of the United States of America, 97 7
- Publisher
- Springer Journals
- Copyright
- Copyright © 2006 by Springer Science+Business Media B.V.
- Subject
- Life Sciences; Plant Pathology; Biochemistry, general; Plant Sciences
- ISSN
- 0167-4412
- eISSN
- 1573-5028
- DOI
- 10.1007/s11103-006-9075-1
- pmid
- 17120136
- Publisher site
- See Article on Publisher Site
Abstract
The sub-cellular location of enzymes of fatty acid β-oxidation in plants is controversial. In the current debate the role and location of particular thiolases in fatty acid degradation, fatty acid synthesis and isoleucine degradation are important. The aim of this research was to determine the sub-cellular location and hence provide information about possible functions of all the putative 3-ketoacyl-CoA thiolases (KAT) and acetoacetyl-CoA thiolases (ACAT) in Arabidopsis. Arabidopsis has three genes predicted to encode KATs, one of which encodes two polypeptides that differ at the N-terminal end. Expression in Arabidopsis cells of cDNAs encoding each of these KATs fused to green fluorescent protein (GFP) at their C-termini showed that three are targeted to peroxisomes while the fourth is apparently cytosolic. The four KATs are also predicted to have mitochondrial targeting sequences, but purified mitochondria were unable to import any of the proteins in vitro. Arabidopsis also has two genes encoding a total of five different putative ACATs. One isoform is targeted to peroxisomes as a fusion with GFP, while the others display no targeting in vivo as GFP fusions, or import into isolated mitochondria. Analysis of gene co-expression clusters in Arabidopsis suggests a role for peroxisomal KAT2 in β-oxidation, while KAT5 co-expresses with genes of the flavonoid biosynthesis pathway and cytosolic ACAT2 clearly co-expresses with genes of the cytosolic mevalonate biosynthesis pathway. We conclude that KATs and ACATs are present in the cytosol and peroxisome, but are not found in mitochondria. The implications for fatty acid β-oxidation and for isoleucine degradation in mitochondria are discussed.
Journal
Plant Molecular Biology – Springer Journals
Published: Nov 21, 2006