Nilotinib Reactions 1680, p252 - 2 Dec 2017 Cutaneous and hepatic toxicities: 2 case reports In a cohort study, wherein patients were enrolled in a prospective as well as retrospective manner, two patients [ages and sexes not stated] were described, who developed hepatic and cutaneous toxicities during treatment with nilotinib. The patients, who had a history of chronic myeloid leukaemia, were started on nilotinib at an initial daily dose 600mg [routes not stated]. Subsequently, one of the two patients developed grade 4 hepatic toxicity, and other patient developed grade 4 cutaneous toxicity [durations of treatments to reactions onsets and outcomes not stated]. Author comment: "[I]n 2 cases toxicity was of grade 4 (one patient with hepatic toxicity, another one with cutaneous toxicity)." Galimberti S, et al. The hOCT1 and ABCB1 polymorphisms do not influence the pharmacodynamics of nilotinib in chronic myeloid leukemia. Oncotarget 8: 88021-88033, No. 50, 30 Sep 2017. Available from: URL: oncotarget.21406 - Italy 803285089 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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