Background Nicotine improves attention and processing speed in individuals with schizophrenia. Few studies have investigated the effects of nicotine on cognitive control. Prior functional magnetic resonance imaging (fMRI) research demonstrates blunted activation of dorsal anterior cingulate cortex (dACC) and rostral anterior cingulate cortex (rACC) in response to error and decreased post-error slowing in schizophrenia. Methods Participants with schizophrenia (n = 13) and healthy controls (n = 12) participated in a randomized, placebo-controlled, crossover study of the effects of transdermal nicotine on cognitive control. For each drug condition, participants underwent fMRI while performing the stop signal task where participants attempt to inhibit prepotent responses to Bgo (motor activation)^ signals when an occasional Bstop (motor inhibition)^ signal appears. Error processing was evaluated by comparing Bstop error^ trials (failed response inhibition) to Bgo^ trials. Resting-state fMRI data were collected prior to the task. Results Participants with schizophrenia had increased nicotine-induced activation of right caudate in response to errors compared to controls (DRUG × GROUP effect: p < 0.05). Both groups had significant nicotine-induced activation of dACC and corrected rACC in response to errors. Using right caudate activation to errors as a seed for resting-state functional connectivity analysis, relative to controls, participants with
Psychopharmacology – Springer Journals
Published: Nov 27, 2017
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