Int J Colorectal Dis (2017) 32:1267–1275 DOI 10.1007/s00384-017-2839-z ORIGINAL ARTICLE Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study 1 1 1 2 Daniël P. V. Lambrichts & Geesien S. A. Boersema & Buket Tas & Zhouqiao Wu & 3 4 4 1,5 Wietske W. Vrijland & Gert-Jan Kleinrensink & Johannes Jeekel & Johan F. Lange & 1,5 Anand G. Menon Accepted: 12 June 2017 /Published online: 28 June 2017 The Author(s) 2017. This article is an open access publication Abstract with normal or nicotine gum (2 mg). Patient reported out- Purpose When postoperative ileus is not resolved after 5 days comes (PROMS), clinical characteristics and blood samples or recurs after resolution, prolonged POI (PPOI) is diagnosed. were collected. Primary endpoint was defined as time to first PPOI increases discomfort, morbidity and hospitalisation passage of faeces and toleration of solid food for at least 24 h. length, and is mainly caused by an inflammatory response Results In total, 40 patients were enrolled (20 vs. 20). In both following intestinal manipulation. This response can be weak- groups, six patients developed PPOI. Time to primary end- ened by targeting the cholinergic
International Journal of Colorectal Disease – Springer Journals
Published: Jun 28, 2017
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