New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism

New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism Journal of Bioenergetics and Biomembranes https://doi.org/10.1007/s10863-018-9762-z EDITORIAL New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism Chad Slawson Received: 14 May 2018 / Accepted: 22 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Metabolism has always been important. However, metabo- prolonged increased or decreased O-GlcNAc levels leads to lism is more than both the catabolic and anabolic functions transcriptional alterations in OGT and OGA (Kazemi et al. that maintain nutrient levels and generate high-energy sub- 2010; Zhang et al. 2014). Thus, the cell maintains a homeo- strates for chemical reactions. Importantly, metabolites de- static level of O-GlcNAcylation that is sensitive to nutrient rived from metabolic processes are used to sense the environ- flux. However, prolonged disruptions in O-GlcNAc homeo- ment and signal within the cells. Cellular metabolites are used stasis due to nutrient excess or metabolic stress contribute to as Bnutrient^ sensors allowing cells to rapidly respond to disease pathogenesis. changes in the cellular environment, nutrient influx, or energy The articles within this issue grapple with implications of levels. Hence, most post-translational modifications derived O-GlcNAc nutrient sensing and disruptions in O-GlcNAc ho- from metabolites are nutrient sensors. Phosphorylation, acet- meostasis in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bioenergetics and Biomembranes Springer Journals

New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism

Loading next page...
 
/lp/springer_journal/new-ways-of-thinking-about-old-things-the-role-of-o-glcnac-in-cellular-jEgaKwOFUw
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Chemistry; Bioorganic Chemistry; Biochemistry, general; Animal Anatomy / Morphology / Histology; Animal Biochemistry; Organic Chemistry
ISSN
0145-479X
eISSN
1573-6881
D.O.I.
10.1007/s10863-018-9762-z
Publisher site
See Article on Publisher Site

Abstract

Journal of Bioenergetics and Biomembranes https://doi.org/10.1007/s10863-018-9762-z EDITORIAL New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism Chad Slawson Received: 14 May 2018 / Accepted: 22 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Metabolism has always been important. However, metabo- prolonged increased or decreased O-GlcNAc levels leads to lism is more than both the catabolic and anabolic functions transcriptional alterations in OGT and OGA (Kazemi et al. that maintain nutrient levels and generate high-energy sub- 2010; Zhang et al. 2014). Thus, the cell maintains a homeo- strates for chemical reactions. Importantly, metabolites de- static level of O-GlcNAcylation that is sensitive to nutrient rived from metabolic processes are used to sense the environ- flux. However, prolonged disruptions in O-GlcNAc homeo- ment and signal within the cells. Cellular metabolites are used stasis due to nutrient excess or metabolic stress contribute to as Bnutrient^ sensors allowing cells to rapidly respond to disease pathogenesis. changes in the cellular environment, nutrient influx, or energy The articles within this issue grapple with implications of levels. Hence, most post-translational modifications derived O-GlcNAc nutrient sensing and disruptions in O-GlcNAc ho- from metabolites are nutrient sensors. Phosphorylation, acet- meostasis in

Journal

Journal of Bioenergetics and BiomembranesSpringer Journals

Published: May 29, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off