Journal of Bioenergetics and Biomembranes https://doi.org/10.1007/s10863-018-9762-z EDITORIAL New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism Chad Slawson Received: 14 May 2018 / Accepted: 22 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Metabolism has always been important. However, metabo- prolonged increased or decreased O-GlcNAc levels leads to lism is more than both the catabolic and anabolic functions transcriptional alterations in OGT and OGA (Kazemi et al. that maintain nutrient levels and generate high-energy sub- 2010; Zhang et al. 2014). Thus, the cell maintains a homeo- strates for chemical reactions. Importantly, metabolites de- static level of O-GlcNAcylation that is sensitive to nutrient rived from metabolic processes are used to sense the environ- flux. However, prolonged disruptions in O-GlcNAc homeo- ment and signal within the cells. Cellular metabolites are used stasis due to nutrient excess or metabolic stress contribute to as Bnutrient^ sensors allowing cells to rapidly respond to disease pathogenesis. changes in the cellular environment, nutrient influx, or energy The articles within this issue grapple with implications of levels. Hence, most post-translational modifications derived O-GlcNAc nutrient sensing and disruptions in O-GlcNAc ho- from metabolites are nutrient sensors. Phosphorylation, acet- meostasis in
Journal of Bioenergetics and Biomembranes – Springer Journals
Published: May 29, 2018
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