New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017

New variants of porcine epidemic diarrhea virus with large deletions in the spike protein,... Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/ JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD- del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes. In spring 2013, porcine epidemic diarrhea virus (PEDV), We detected the first S INDEL strain of PEDV in the an alphacoronavirus, emerged for the first time in the US, US and isolated several original US and S INDEL PEDV causing large-scale outbreaks in swine farms and the deaths strains and a unique variant in Vero http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017

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Publisher
Springer Vienna
Copyright
Copyright © 2018 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-018-3874-y
Publisher site
See Article on Publisher Site

Abstract

Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/ JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD- del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes. In spring 2013, porcine epidemic diarrhea virus (PEDV), We detected the first S INDEL strain of PEDV in the an alphacoronavirus, emerged for the first time in the US, US and isolated several original US and S INDEL PEDV causing large-scale outbreaks in swine farms and the deaths strains and a unique variant in Vero

Journal

Archives of VirologySpringer Journals

Published: May 22, 2018

References

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