New tetrazoloquinolinyl methoxyphenyl-4-thiazolidinones: synthesis and antihyperglycemic evaluation

New tetrazoloquinolinyl methoxyphenyl-4-thiazolidinones: synthesis and antihyperglycemic evaluation Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2686-5) contains supplementary material, which is available to authorized users. & Ramrao A. Mane Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS 431004, India Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India 123 1108 A. R. Deshmukh et al. Keywords Diabetes mellitus  Antihyperglycemic agents Tetrazolo[1,5-a]quinoline  4-Thiazolidinones Introduction Diabetes mellitus is a major metabolic disorder, being considered to be one of the greatest health catastrophes in the world. Approximately 415 million people are affected by diabetes, and this number is predicted to increase to 642 million by 2040 [1]. Non-insulin-dependent diabetes mellitus (NIDDM/type 2) is the most predom- inant form of diabetes; it is a complex metabolic disorder with multiple heterogeneous etiologies, characterized by insulin resistance and impaired insulin secretion. These metabolic disorders cause hyperglycemia, which is significantly responsible for diabetic complications [2–4]. Microangiopathic complications of untreated or inadequately treated diabetes include neuropathy, nephropathy, retinopathy, obesity, dyslipidemia, hypertension, and other cardiovascular diseases. These are believed to be triggered by excessive protein glycation due to the higher level of circulating glucose, i.e., hyperglycemia [5–9]. Hence, in recent years, several researchers have focused their attention on development Research on Chemical Intermediates Springer Journals

New tetrazoloquinolinyl methoxyphenyl-4-thiazolidinones: synthesis and antihyperglycemic evaluation

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial