Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2686-5) contains supplementary material, which is available to authorized users. & Ramrao A. Mane firstname.lastname@example.org Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS 431004, India Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India 123 1108 A. R. Deshmukh et al. Keywords Diabetes mellitus Antihyperglycemic agents Tetrazolo[1,5-a]quinoline 4-Thiazolidinones Introduction Diabetes mellitus is a major metabolic disorder, being considered to be one of the greatest health catastrophes in the world. Approximately 415 million people are affected by diabetes, and this number is predicted to increase to 642 million by 2040 . Non-insulin-dependent diabetes mellitus (NIDDM/type 2) is the most predom- inant form of diabetes; it is a complex metabolic disorder with multiple heterogeneous etiologies, characterized by insulin resistance and impaired insulin secretion. These metabolic disorders cause hyperglycemia, which is signiﬁcantly responsible for diabetic complications [2–4]. Microangiopathic complications of untreated or inadequately treated diabetes include neuropathy, nephropathy, retinopathy, obesity, dyslipidemia, hypertension, and other cardiovascular diseases. These are believed to be triggered by excessive protein glycation due to the higher level of circulating glucose, i.e., hyperglycemia [5–9]. Hence, in recent years, several researchers have focused their attention on development
Research on Chemical Intermediates – Springer Journals
Published: Aug 10, 2016
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