New Semi-Synthetic Derivatives of Capsaicinoids and Their Antioxidant Activities

New Semi-Synthetic Derivatives of Capsaicinoids and Their Antioxidant Activities DOI 10.1007/s10600-018-2403-2 Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 NEW SEMI-SYNTHETIC DERIVATIVES OF CAPSAICINOIDS AND THEIR ANTIOXIDANT ACTIVITIES 1 1 1 P. Kumboonma, C. Ruangviriyachai, P. Khansawai, 2 1* P. Karitpattawan, and C. Phaosiri Capsaicin (1, CAP) is one of the major pungent molecules found in hot chili peppers (Capsicum spp.). Besides capsaicin, dihydrocapsaicin (2, DHC) shows a similar burning sensation. A variety of capsaicinoid biological activities has been reported, including stimulation of cardiovascular and respiratory systems as well as suppression of growth of cancer cells [1, 2]. In order to better understand antioxidant activity and the role played by different functional groups apart from the phenolic group of capsaicinoids, four capsaicin and dihydrocapsaicin derivatives were designed and newly synthesized in this work. Dried fruits of Capsicum annuum (1 kg) were purchased from the local market in Khon Kaen, Thailand. The dried fruits of C. annuum were extracted with ethyl acetate. Next, the ethyl acetate extract was concentrated and extracted with NaOH solution. The pH of the basic extract was adjusted to acidic with HCl, and it was further extracted with ethyl acetate. The final ethyl acetate extract was concentrated and purified. The 1:1 mixture of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Natural Compounds Springer Journals

New Semi-Synthetic Derivatives of Capsaicinoids and Their Antioxidant Activities

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Organic Chemistry; Plant Sciences
ISSN
0009-3130
eISSN
1573-8388
D.O.I.
10.1007/s10600-018-2403-2
Publisher site
See Article on Publisher Site

Abstract

DOI 10.1007/s10600-018-2403-2 Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 NEW SEMI-SYNTHETIC DERIVATIVES OF CAPSAICINOIDS AND THEIR ANTIOXIDANT ACTIVITIES 1 1 1 P. Kumboonma, C. Ruangviriyachai, P. Khansawai, 2 1* P. Karitpattawan, and C. Phaosiri Capsaicin (1, CAP) is one of the major pungent molecules found in hot chili peppers (Capsicum spp.). Besides capsaicin, dihydrocapsaicin (2, DHC) shows a similar burning sensation. A variety of capsaicinoid biological activities has been reported, including stimulation of cardiovascular and respiratory systems as well as suppression of growth of cancer cells [1, 2]. In order to better understand antioxidant activity and the role played by different functional groups apart from the phenolic group of capsaicinoids, four capsaicin and dihydrocapsaicin derivatives were designed and newly synthesized in this work. Dried fruits of Capsicum annuum (1 kg) were purchased from the local market in Khon Kaen, Thailand. The dried fruits of C. annuum were extracted with ethyl acetate. Next, the ethyl acetate extract was concentrated and extracted with NaOH solution. The pH of the basic extract was adjusted to acidic with HCl, and it was further extracted with ethyl acetate. The final ethyl acetate extract was concentrated and purified. The 1:1 mixture of

Journal

Chemistry of Natural CompoundsSpringer Journals

Published: Jun 7, 2018

References

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