ISSN 0891-4168, Molecular Genetics, Microbiology and Virology, 2017, Vol. 32, No. 4, pp. 218–223. © Allerton Press, Inc., 2017. EXPERIMENTAL WORKS New Mutations in Ciprof loxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan Province, Northern Iran a b, b Saeid Rahbar Takrami , Najmeh Ranji *, and Fatemeh Hakimi Young Researchers and Elite Club, Rasht Branch, Islamic Azad University, Rasht, Iran Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran *e-mail: email@example.com Received August 17, 2017 Abstract—Introduction. Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative bacterium that continues to be a major cause of opportunistic nosocomial infections. In P. aeruginosa, several f luoroquinolones resis- tance mechanisms have been proposed such as mutations in the target enzymes GyrA and ParC and upregu- lation of efflux pump MexAB-OprM. Fluoroquinolones inhibit the target enzymes DNA gyrase and topoisomerase IV, each comprised of two subunits: GyrA and GyrB, and ParC and ParE, respectively. In addi- tion, f luoroquinolones were blocked by overexpression of MexAB-OprM induced through mutations in the regulatory genes mexR and nalC. Materials and methods. In this study, 44 P. aeruginosa strains were isolated from different clinical samples of burn and infection from patients in some hospitals
Molecular Genetics, Microbiology and Virology – Springer Journals
Published: May 30, 2018
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