New Mutations in Ciprofloxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan Province, Northern Iran

New Mutations in Ciprofloxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan... ISSN 0891-4168, Molecular Genetics, Microbiology and Virology, 2017, Vol. 32, No. 4, pp. 218–223. © Allerton Press, Inc., 2017. EXPERIMENTAL WORKS New Mutations in Ciprof loxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan Province, Northern Iran a b, b Saeid Rahbar Takrami , Najmeh Ranji *, and Fatemeh Hakimi Young Researchers and Elite Club, Rasht Branch, Islamic Azad University, Rasht, Iran Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran *e-mail: n_ranji@iaurasht.ac.ir Received August 17, 2017 Abstract—Introduction. Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative bacterium that continues to be a major cause of opportunistic nosocomial infections. In P. aeruginosa, several f luoroquinolones resis- tance mechanisms have been proposed such as mutations in the target enzymes GyrA and ParC and upregu- lation of efflux pump MexAB-OprM. Fluoroquinolones inhibit the target enzymes DNA gyrase and topoisomerase IV, each comprised of two subunits: GyrA and GyrB, and ParC and ParE, respectively. In addi- tion, f luoroquinolones were blocked by overexpression of MexAB-OprM induced through mutations in the regulatory genes mexR and nalC. Materials and methods. In this study, 44 P. aeruginosa strains were isolated from different clinical samples of burn and infection from patients in some hospitals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Genetics, Microbiology and Virology Springer Journals

New Mutations in Ciprofloxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan Province, Northern Iran

Loading next page...
 
/lp/springer_journal/new-mutations-in-ciprofloxacin-resistant-strains-of-pseudomonas-f8yWGK1NyC
Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Allerton Press, Inc.
Subject
Life Sciences; Microbiology; Molecular Medicine
ISSN
0891-4168
eISSN
1934-841X
D.O.I.
10.3103/S089141681704005X
Publisher site
See Article on Publisher Site

Abstract

ISSN 0891-4168, Molecular Genetics, Microbiology and Virology, 2017, Vol. 32, No. 4, pp. 218–223. © Allerton Press, Inc., 2017. EXPERIMENTAL WORKS New Mutations in Ciprof loxacin Resistant Strains of Pseudomonas aeruginosa Isolated from Guilan Province, Northern Iran a b, b Saeid Rahbar Takrami , Najmeh Ranji *, and Fatemeh Hakimi Young Researchers and Elite Club, Rasht Branch, Islamic Azad University, Rasht, Iran Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran *e-mail: n_ranji@iaurasht.ac.ir Received August 17, 2017 Abstract—Introduction. Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative bacterium that continues to be a major cause of opportunistic nosocomial infections. In P. aeruginosa, several f luoroquinolones resis- tance mechanisms have been proposed such as mutations in the target enzymes GyrA and ParC and upregu- lation of efflux pump MexAB-OprM. Fluoroquinolones inhibit the target enzymes DNA gyrase and topoisomerase IV, each comprised of two subunits: GyrA and GyrB, and ParC and ParE, respectively. In addi- tion, f luoroquinolones were blocked by overexpression of MexAB-OprM induced through mutations in the regulatory genes mexR and nalC. Materials and methods. In this study, 44 P. aeruginosa strains were isolated from different clinical samples of burn and infection from patients in some hospitals

Journal

Molecular Genetics, Microbiology and VirologySpringer Journals

Published: May 30, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off