New Insights: MicroRNA Function in CNS Development and Psychiatric Diseases

New Insights: MicroRNA Function in CNS Development and Psychiatric Diseases Purpose of Review Here, we concisely review microRNA (miRNA)-related research publications on the central nervous system (CNS) development (focusing on the forebrain and the cerebellum) and related psychiatric diseases over the past 3 years. We intend to summarize the new insights from these publications and, at the same time, provide personal views on some of the important mechanistic questions in the field. Recent Findings MiRNAs, a type of small non-coding RNA molecules, have emerged as essential players in many biological processes. During CNS development, miRNAs have also been shown to exert their posttranscriptional regulation in numerous developmental events acting from master regulators to fine tuners of gene expression. While a single miRNA miR-980 regulates neuronal excitability and leads to alterations in behaviors associated with memory, sometimes multiple miRNAs have to functionally converge to induce one developmental process. Recent findings identified novel target genes for selected miRNAs during distinct developmental processes, and highlighted their important functions in several signaling pathways. Meanwhile, abnormal function of miRNAs during CNS development could lead to psychiatric diseases later on in life. Indeed, genomic variants, microdeletion, and microduplication could directly or indirectly involve miRNAs in the onset of these psychiatric diseases. Summary Over the years, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Pharmacology Reports Springer Journals

New Insights: MicroRNA Function in CNS Development and Psychiatric Diseases

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Biomedicine, general; Cancer Research; Molecular Medicine
eISSN
2198-641X
D.O.I.
10.1007/s40495-018-0129-2
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Here, we concisely review microRNA (miRNA)-related research publications on the central nervous system (CNS) development (focusing on the forebrain and the cerebellum) and related psychiatric diseases over the past 3 years. We intend to summarize the new insights from these publications and, at the same time, provide personal views on some of the important mechanistic questions in the field. Recent Findings MiRNAs, a type of small non-coding RNA molecules, have emerged as essential players in many biological processes. During CNS development, miRNAs have also been shown to exert their posttranscriptional regulation in numerous developmental events acting from master regulators to fine tuners of gene expression. While a single miRNA miR-980 regulates neuronal excitability and leads to alterations in behaviors associated with memory, sometimes multiple miRNAs have to functionally converge to induce one developmental process. Recent findings identified novel target genes for selected miRNAs during distinct developmental processes, and highlighted their important functions in several signaling pathways. Meanwhile, abnormal function of miRNAs during CNS development could lead to psychiatric diseases later on in life. Indeed, genomic variants, microdeletion, and microduplication could directly or indirectly involve miRNAs in the onset of these psychiatric diseases. Summary Over the years,

Journal

Current Pharmacology ReportsSpringer Journals

Published: Feb 22, 2018

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