Eur Arch Psychiatry Clin Neurosci (2017) 267:485–486 DOI 10.1007/s00406-017-0825-7 EDITORIAL New aspects of the vulnerability stress model in general, its relevance in schizophrenic psychoses and the place of antipsychotics Hans‑Jürgen Möller Published online: 19 July 2017 © Springer-Verlag GmbH Germany 2017 Originally, the vulnerability stress model was developed licensed indications—so-called traditional compounds like in the context of schizophrenic psychoses to give a better antidepressants, antipsychotics, anxiolytics or in the new insight into the complexity of the multifactorial etiopatho- nomenclature  more specifically according to their main genesis of these disorders and to provide a roadmap for dif- pharmacological properties: serotonin/norepinephrine reup- ferent kinds of interventions in terms of psychopharmaco- take inhibitors, serotonin reuptake inhibitors, alpha-2 recep- logical and psychosocial treatments [2, 5, 10, 11]. Later on tor antagonists, dopamine receptor antagonists, dopamine it seemed adequate to extend this conceptual approach to serotonin antagonists, benzodiazepine receptor agonists, other mental disorders. etc. Considering these pharmacological mechanisms allows In the current issue of EAPC, several papers are related a more extended use related to syndromal or symptomatic to stress in its diverse manifestations under different condi - aspects, independent from classificatory clusters [ 8, 12]. All tions and in the context of different mental disorders like the pharmacological mechanisms
European Archives of Psychiatry and Clinical Neuroscience – Springer Journals
Published: Jul 19, 2017
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