A new series of 2-(5-substituted-pyridazine-3,6-dion-4-yl)perimidine derivatives was synthesized in good yields via reaction of (1H-perimidin-2-yl) acetic acid hydrazide with ethyl N-arylhydrazonochloroacetate in dioxane in the presence of triethylamine reagent. The site selectivity of the studied reaction is discussed, and the structure of the products is established based on elemental and spectral data. Also, the antimicrobial activity of the products was evaluated with promising results being obtained.
Research on Chemical Intermediates – Springer Journals
Published: Dec 18, 2013
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