New 2-heterocyclic perimidines: synthesis and antimicrobial activity

New 2-heterocyclic perimidines: synthesis and antimicrobial activity A new series of 2-(5-substituted-pyridazine-3,6-dion-4-yl)perimidine derivatives was synthesized in good yields via reaction of (1H-perimidin-2-yl) acetic acid hydrazide with ethyl N-arylhydrazonochloroacetate in dioxane in the presence of triethylamine reagent. The site selectivity of the studied reaction is discussed, and the structure of the products is established based on elemental and spectral data. Also, the antimicrobial activity of the products was evaluated with promising results being obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

New 2-heterocyclic perimidines: synthesis and antimicrobial activity

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Publisher
Springer Netherlands
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-013-1501-9
Publisher site
See Article on Publisher Site

Abstract

A new series of 2-(5-substituted-pyridazine-3,6-dion-4-yl)perimidine derivatives was synthesized in good yields via reaction of (1H-perimidin-2-yl) acetic acid hydrazide with ethyl N-arylhydrazonochloroacetate in dioxane in the presence of triethylamine reagent. The site selectivity of the studied reaction is discussed, and the structure of the products is established based on elemental and spectral data. Also, the antimicrobial activity of the products was evaluated with promising results being obtained.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Dec 18, 2013

References

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