Results of earlier investigations have demonstrated impaired function of polymorph-nuclear cells (PMN) in previously irradiated tissue. This study was designed to examine the effect of local oxygen pressure (pO 2 ) on neutrophil function in irradiated tissue. By choosing a pig model of irradiated and non-irradiated high perfusion wound environment (i.e. musculo-cutaneous (MC) flap) vs. a poor perfusion wound environment (i.e. random pattern (RP) skin flap), the effect of different pO 2 levels on neutrophil phagocytosis and respiratory burst (H 2 O 2 production) were measured at 6, 12, and 16 weeks after irradiation. In both kinds of irradiated flaps, pO 2 levels and neutrophil function were significantly lower (RP: <20 mmHg; MC: 30 mmHg) than in corresponding flaps from non-irradiated tissue (RP: 26–28 mmHg; MC: 30–40 mmHg) and showed a progressive decline with increasing time interval after irradiation. Correlation between pO 2 and phagocytosis ( p =0.001) and H 2 O 2 production ( p =0.02) proved to be statistically significant for the irradiated random pattern flaps, but not for musculocutaneous flaps.
European Journal of Plastic Surgery – Springer Journals
Published: Jan 1, 1998
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