Neurotoxicity of cyclosporineA in children with steroid-resistant nephrotic syndrome: is cytotoxic edema really an unfavorable predictor of permanent neurological damage?

Neurotoxicity of cyclosporineA in children with steroid-resistant nephrotic syndrome: is... short report Wien Klin Wochenschr (2017) 129:579–582 DOI 10.1007/s00508-017-1221-z Neurotoxicity of cyclosporine A in children with steroid- resistant nephrotic syndrome: is cytotoxic edema really an unfavorable predictor of permanent neurological damage? Danica Batinic´ · Danko Milose ˇ vic´ · Boris Filipovic- ´ Grci ˇ c´ · Marija Topalovic- ´ Grkovic·N ´ ina Barisiˇ c·D ´ aniel Turudic´ Received: 26 October 2015 / Accepted: 23 May 2017 / Published online: 9 June 2017 © Springer-Verlag Wien 2017 Summary cyclosporine A discontinuation and supportive ther- Background Cyclosporine A-associated neurotoxicity apy. has been reported mainly after organ transplantation. Only a small number of children with steroid-resis- Keywords Cyclosporine A neurotoxicity · Steroid-re- tant nephrotic syndrome and cyclosporine A-associ- sistant nephrotic syndrome · Children ated neurotoxicity have been reported. Patients We report three children, aged 4, 11, and Introduction 15, with steroid-resistant nephrotic syndrome and cyclosporine A-associated neurotoxicity. In two of the Cyclosporine A (CyA)-associated neurotoxicity has patients, primary diagnosis was idiopathic nephrotic been reported mainly after organ transplantation [1]. syndrome, and in one it was IgA nephropathy. Mag- We present three children who developed neurotoxi- netic resonance with diffusion-weighted imaging, city during CyA therapy of steroid-resistant nephrotic combined with quantification of apparent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Wiener klinische Wochenschrift Springer Journals

Neurotoxicity of cyclosporineA in children with steroid-resistant nephrotic syndrome: is cytotoxic edema really an unfavorable predictor of permanent neurological damage?

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Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag Wien
Subject
Medicine & Public Health; Medicine/Public Health, general; Internal Medicine; Endocrinology; Gastroenterology; Pneumology/Respiratory System
ISSN
0043-5325
eISSN
1613-7671
D.O.I.
10.1007/s00508-017-1221-z
Publisher site
See Article on Publisher Site

Abstract

short report Wien Klin Wochenschr (2017) 129:579–582 DOI 10.1007/s00508-017-1221-z Neurotoxicity of cyclosporine A in children with steroid- resistant nephrotic syndrome: is cytotoxic edema really an unfavorable predictor of permanent neurological damage? Danica Batinic´ · Danko Milose ˇ vic´ · Boris Filipovic- ´ Grci ˇ c´ · Marija Topalovic- ´ Grkovic·N ´ ina Barisiˇ c·D ´ aniel Turudic´ Received: 26 October 2015 / Accepted: 23 May 2017 / Published online: 9 June 2017 © Springer-Verlag Wien 2017 Summary cyclosporine A discontinuation and supportive ther- Background Cyclosporine A-associated neurotoxicity apy. has been reported mainly after organ transplantation. Only a small number of children with steroid-resis- Keywords Cyclosporine A neurotoxicity · Steroid-re- tant nephrotic syndrome and cyclosporine A-associ- sistant nephrotic syndrome · Children ated neurotoxicity have been reported. Patients We report three children, aged 4, 11, and Introduction 15, with steroid-resistant nephrotic syndrome and cyclosporine A-associated neurotoxicity. In two of the Cyclosporine A (CyA)-associated neurotoxicity has patients, primary diagnosis was idiopathic nephrotic been reported mainly after organ transplantation [1]. syndrome, and in one it was IgA nephropathy. Mag- We present three children who developed neurotoxi- netic resonance with diffusion-weighted imaging, city during CyA therapy of steroid-resistant nephrotic combined with quantification of apparent

Journal

Wiener klinische WochenschriftSpringer Journals

Published: Jun 9, 2017

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