Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder involving changes in normal bowel movements. The pathophysiology of IBS is not clearly understood owing to the lack of identifiable pathological abnormali - ties and reliable biomarkers. Aim The aim of this study was to discover the novel and reliable biomarker for IBS. Method In this study, neonatal maternal separation (NMS) stress model was used for the IBS mouse model. Further assess- ment was conducted with whole gastrointestinal transit test, quantitative RT-PCR, histological examination, and western blot. Results Male pups developed symptoms similar to those of human IBS with diarrhea (IBS-D), such as low-grade inflamma - tion, stool irregularity, and increased bowel motility. NMS stress influenced to the interstitial cells of Cajal (ICC) and induced altered bowel motility, resulting in IBS-D-like symptoms. In addition, we found neuronal nitric oxide synthase (nNOS) to be a novel biomarker for ICC under NMS stress. nNOS expression was only observed in the ICC of the submucosal plexus of IBS-D mice, and the inhibition of nNOS changed the phenotype from IBS-D to IBS with constipation. Conclusion Our study demonstrates that early-life stress can influence to ICC and modulate bowel activity and that nNOS might
Digestive Diseases and Sciences – Springer Journals
Published: Jan 25, 2018
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